Man–to–woman sexual transmission of HIV

Longitudinal study of 343 steady partners of infected men

Alberto Saracco, Massimo Musicco, Alfredo Nicolosi, Gioacchino Angarano, Claudio Arici, Giovanna Gavazzeni, Paolo Costigliola, Sergio Gafa, Cristina Gervasoni, Roberto Luzzati, Felice Piccinino, Francesco Puppo, Bernardino Salassa, Alessando Sinicco, Roberto Stellini, Umberto Tirelli, Giuseppe Turbessi, Gian Marco Vigevani, Giuseppe Visco, Roberto Zerboni & 1 others Adriano Lazzarin

Research output: Contribution to journalArticle

182 Citations (Scopus)

Abstract

To study incidence and risk factors of heterosexually transmitted HIV infection, we followed a cohort of 343 seronegative women, stable, monogamous partners of infected men whose only risk of acquiring HIV was sexual exposure to the infected partner. Nineteen seroconversions occurred in 529.6 person years (py) of observation, yielding an incidence rate of 3.6 per 100 py. The incidence rate was 7.2 per 100 py among women who did not always use or never used condoms and 1.1 among those who always used them [relative risk (RR) 6.6, 95% confidence interval (CI) 1.9–21.9]. Anal sex was associated with a risk increase in only those women not always using condoms (RR 1.4, 95% CI 0.4–4.8). No seroconversions were observed among 22 women using oral contraceptives. One of the women using intrauterine devices seroconverted. In couples who did not always use condoms, seroconversions occurred more frequently in partners of men with symptomatic diseases, with a low CD4 + cell number (3) or with a detectable p24 antigen. In couples not always using condoms and where the man had a low CD4+ cell count, the joint presence of blood viral antigens and AIDS symptoms conditioned a fivefold increased risk of seroconversion of the woman (RR 5.4, CI 1.4–20.3). At multivariate analysis, women with longer relationships (>1 year) showed a lower risk of seroconversion (RR 0.3, CI 0.1–0.8), and those partners of men positive for p24 antigen in serum had an increased risk of seroconversion (RR = 4.0, CI 0.1–0.8).

Original languageEnglish
Pages (from-to)497-502
Number of pages6
JournalJournal of Acquired Immune Deficiency Syndromes
Volume6
Issue number5
Publication statusPublished - 1993

Fingerprint

Longitudinal Studies
HIV
Condoms
Confidence Intervals
Antigens
Intrauterine Devices
Viral Antigens
Incidence
CD4 Lymphocyte Count
Oral Contraceptives
Sexual Behavior
HIV Infections
Seroconversion
Acquired Immunodeficiency Syndrome
Cohort Studies
Multivariate Analysis
Cell Count
Joints
Observation
Serum

Keywords

  • Heterosexually transmitted HIV
  • Risk factors
  • Seroconversion

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)
  • Immunology and Allergy
  • Virology

Cite this

Saracco, A., Musicco, M., Nicolosi, A., Angarano, G., Arici, C., Gavazzeni, G., ... Lazzarin, A. (1993). Man–to–woman sexual transmission of HIV: Longitudinal study of 343 steady partners of infected men. Journal of Acquired Immune Deficiency Syndromes, 6(5), 497-502.

Man–to–woman sexual transmission of HIV : Longitudinal study of 343 steady partners of infected men. / Saracco, Alberto; Musicco, Massimo; Nicolosi, Alfredo; Angarano, Gioacchino; Arici, Claudio; Gavazzeni, Giovanna; Costigliola, Paolo; Gafa, Sergio; Gervasoni, Cristina; Luzzati, Roberto; Piccinino, Felice; Puppo, Francesco; Salassa, Bernardino; Sinicco, Alessando; Stellini, Roberto; Tirelli, Umberto; Turbessi, Giuseppe; Vigevani, Gian Marco; Visco, Giuseppe; Zerboni, Roberto; Lazzarin, Adriano.

In: Journal of Acquired Immune Deficiency Syndromes, Vol. 6, No. 5, 1993, p. 497-502.

Research output: Contribution to journalArticle

Saracco, A, Musicco, M, Nicolosi, A, Angarano, G, Arici, C, Gavazzeni, G, Costigliola, P, Gafa, S, Gervasoni, C, Luzzati, R, Piccinino, F, Puppo, F, Salassa, B, Sinicco, A, Stellini, R, Tirelli, U, Turbessi, G, Vigevani, GM, Visco, G, Zerboni, R & Lazzarin, A 1993, 'Man–to–woman sexual transmission of HIV: Longitudinal study of 343 steady partners of infected men', Journal of Acquired Immune Deficiency Syndromes, vol. 6, no. 5, pp. 497-502.
Saracco, Alberto ; Musicco, Massimo ; Nicolosi, Alfredo ; Angarano, Gioacchino ; Arici, Claudio ; Gavazzeni, Giovanna ; Costigliola, Paolo ; Gafa, Sergio ; Gervasoni, Cristina ; Luzzati, Roberto ; Piccinino, Felice ; Puppo, Francesco ; Salassa, Bernardino ; Sinicco, Alessando ; Stellini, Roberto ; Tirelli, Umberto ; Turbessi, Giuseppe ; Vigevani, Gian Marco ; Visco, Giuseppe ; Zerboni, Roberto ; Lazzarin, Adriano. / Man–to–woman sexual transmission of HIV : Longitudinal study of 343 steady partners of infected men. In: Journal of Acquired Immune Deficiency Syndromes. 1993 ; Vol. 6, No. 5. pp. 497-502.
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