MAO A VNTR polymorphism and amygdala volume in healthy subjects

Antonio Cerasa, Aldo Quattrone, Maria C. Gioia, Angela Magariello, Maria Muglia, Francesca Assogna, Sergio Bernardini, Carlo Caltagirone, Paola Bossù, Gianfranco Spalletta

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

The X-linked Monoamine Oxidase A (MAO A) gene presents a well known functional polymorphism consisting of a variable number of tandem repeats (VNTR) (long and short variants) previously associated with altered neural function of the amygdala. Using automatic subcortical segmentation (Freesurfer), we investigated whether amygdala volume could be influenced by this genotype. We studied 109 healthy subjects (age range 18-80. years; 59 male and 50 female), 74 carrying the MAO A High-activity allele and 35 the MAO A Low-activity allele. No significant effect of the MAO A polymorphism or interaction effect between polymorphism × gender was found on amygdalar volume. Thus, our findings suggest that the reported impact of the MAO A polymorphism on amygdala function is not coupled with consistent volumetric changes in healthy subjects. Future studies are needed to investigate whether the association between volume of the amygdala and the MAO A VNTR polymorphism is influenced by social/psychological variables, such as impulsivity, trauma history and cigarette smoking behaviour, not taken into account in this work.

Original languageEnglish
Pages (from-to)87-91
Number of pages5
JournalPsychiatry Research - Neuroimaging
Volume191
Issue number2
DOIs
Publication statusPublished - Feb 28 2011

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Minisatellite Repeats
Monoamine Oxidase
Amygdala
Healthy Volunteers
Alleles
Impulsive Behavior
Smoking
Genotype
Psychology
Wounds and Injuries
Genes

Keywords

  • Amygdala volume
  • Automated subcortical segmentation
  • Imaging genetics
  • MAO A variable number of tandem repeats (VNTR) genotype

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Radiology Nuclear Medicine and imaging
  • Neuroscience (miscellaneous)

Cite this

MAO A VNTR polymorphism and amygdala volume in healthy subjects. / Cerasa, Antonio; Quattrone, Aldo; Gioia, Maria C.; Magariello, Angela; Muglia, Maria; Assogna, Francesca; Bernardini, Sergio; Caltagirone, Carlo; Bossù, Paola; Spalletta, Gianfranco.

In: Psychiatry Research - Neuroimaging, Vol. 191, No. 2, 28.02.2011, p. 87-91.

Research output: Contribution to journalArticle

Cerasa, A, Quattrone, A, Gioia, MC, Magariello, A, Muglia, M, Assogna, F, Bernardini, S, Caltagirone, C, Bossù, P & Spalletta, G 2011, 'MAO A VNTR polymorphism and amygdala volume in healthy subjects', Psychiatry Research - Neuroimaging, vol. 191, no. 2, pp. 87-91. https://doi.org/10.1016/j.pscychresns.2010.11.002
Cerasa A, Quattrone A, Gioia MC, Magariello A, Muglia M, Assogna F et al. MAO A VNTR polymorphism and amygdala volume in healthy subjects. Psychiatry Research - Neuroimaging. 2011 Feb 28;191(2):87-91. https://doi.org/10.1016/j.pscychresns.2010.11.002
Cerasa, Antonio ; Quattrone, Aldo ; Gioia, Maria C. ; Magariello, Angela ; Muglia, Maria ; Assogna, Francesca ; Bernardini, Sergio ; Caltagirone, Carlo ; Bossù, Paola ; Spalletta, Gianfranco. / MAO A VNTR polymorphism and amygdala volume in healthy subjects. In: Psychiatry Research - Neuroimaging. 2011 ; Vol. 191, No. 2. pp. 87-91.
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