Mapping and ablation: A worldwide perspective

Currently, many ablative techniques have reported excellent long-term results in restoring and maintaining sinus rhythm among patients with paroxysmal and persistent AF. Catheter ablation of AF should not be performed too late over time when recurrent paroxysmal AF progresses to the persistent or to the permanent form. Among patients with permanent AF, the stepwise approach requires very extensive lesions in both the left and right atrium to obtain the same success rate as reported by CPVA as performed in Milan many years ago. Long-term prospective multicenter randomized studies comparing the impact of medical therapy with catheter ablation strategy on "hard" outcomes such as morbidity and mortality are required to better define the patient population that may mostly benefit from ablation at the lowest risk and acceptable cost.