Mapping brain morphological and functional conversion patterns in amnestic MCI: A voxel-based MRI and FDG-PET study

Silvia Morbelli, Arnoldo Piccardo, Giampiero Villavecchia, Barbara Dessi, Andrea Brugnolo, Alessandra Piccini, Anna Caroli, Giovanni Frisoni, Guido Rodriguez, Flavio Nobili

Research output: Contribution to journalArticlepeer-review


Purpose: To reveal the morphological and functional substrates of memory impairment and conversion to Alzheimer disease (AD) from the stage of amnestic mild cognitive impairment (aMCI). Methods: Brain MRI and FDG-PET were performed in 20 patients with aMCI and 12 controls at baseline. During a mean follow-up of about 2 years, 9 patients developed AD (converters), and 11 did not (nonconverters). All images were processed with SPM2. FDG-PET and segmented grey matter (GM) images were compared in: (1) converters versus controls, (2) nonconverters versus controls, and (3) converters versus nonconverters. Results: As compared to controls, converters showed lower GM density in the left parahippocampal gyrus and both thalami, and hypometabolism in the precuneus, posterior cingulate and superior parietal lobule in the left hemisphere. Hypometabolism was found in nonconverters as compared to controls in the left precuneus and posterior cingulated gyrus. As compared to nonconverters, converters showed significant hypometabolism in the left middle and superior temporal gyri. Conclusion: The discordant topography between atrophy and hypometabolism reported in AD is already present at the aMCI stage. Posterior cingulate-precuneus hypometabolism seemed to be an early sign of memory deficit, whereas hypometabolism in the left temporal cortex marked the conversion to AD.

Original languageEnglish
Pages (from-to)36-45
Number of pages10
JournalEuropean Journal of Nuclear Medicine and Molecular Imaging
Issue number1
Publication statusPublished - Jan 2010


  • Alzheimer's disease
  • Alzheimer's disease biomarkers
  • Brain PET
  • Mild cognitive impairment
  • Voxel based morphometry

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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