Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder

Findings From the ENIGMA Consortium

ENIGMA-OCD Working Group

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. Methods: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. Results: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = −0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. Conclusions: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.

Original languageEnglish
JournalBiological Psychiatry
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Obsessive-Compulsive Disorder
Meta-Analysis
Pediatrics
Brain
Globus Pallidus
Thalamus
Quality Control
Comorbidity
Healthy Volunteers
Anxiety
Magnetic Resonance Imaging
Depression
Datasets

Keywords

  • Brain asymmetry
  • Laterality
  • Mega-analysis
  • Obsessive-compulsive disorder
  • Pallidum
  • Thalamus

ASJC Scopus subject areas

  • Biological Psychiatry

Cite this

Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder : Findings From the ENIGMA Consortium. / ENIGMA-OCD Working Group.

In: Biological Psychiatry, 01.01.2019.

Research output: Contribution to journalArticle

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title = "Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder: Findings From the ENIGMA Consortium",
abstract = "Background: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. Methods: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. Results: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = −0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. Conclusions: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.",
keywords = "Brain asymmetry, Laterality, Mega-analysis, Obsessive-compulsive disorder, Pallidum, Thalamus",
author = "{ENIGMA-OCD Working Group} and Kong, {Xiang Zhen} and Boedhoe, {Premika S.W.} and Yoshinari Abe and Pino Alonso and Ameis, {Stephanie H.} and Arnold, {Paul D.} and Francesca Assogna and Baker, {Justin T.} and Batistuzzo, {Marcelo C.} and Francesco Benedetti and Beucke, {Jan C.} and Irene Bollettini and Anushree Bose and Silvia Brem and Brennan, {Brian P.} and Jan Buitelaar and Rosa Calvo and Yuqi Cheng and Cho, {Kang Ik K.} and Sara Dallaspezia and Damiaan Denys and Ely, {Benjamin A.} and Jamie Feusner and Fitzgerald, {Kate D.} and Fouche, {Jean Paul} and Fridgeirsson, {Egill A.} and Glahn, {David C.} and Patricia Gruner and G{\"u}rsel, {Deniz A.} and Hauser, {Tobias U.} and Yoshiyuki Hirano and Hoexter, {Marcelo Q.} and Hao Hu and Chaim Huyser and Anthony James and Fern Jaspers-Fayer and Norbert Kathmann and Christian Kaufmann and Kathrin Koch and Masaru Kuno and Gerd Kvale and Kwon, {Jun Soo} and Fabrizio Piras and Fabrizio Piras and Gianfranco Spalletta and Nerisa Banaj and Valentina Ciullo and Andrea Falini and Sara Poletti and Daniela Vecchio",
year = "2019",
month = "1",
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doi = "10.1016/j.biopsych.2019.04.022",
language = "English",
journal = "Biological Psychiatry",
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T1 - Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder

T2 - Findings From the ENIGMA Consortium

AU - ENIGMA-OCD Working Group

AU - Kong, Xiang Zhen

AU - Boedhoe, Premika S.W.

AU - Abe, Yoshinari

AU - Alonso, Pino

AU - Ameis, Stephanie H.

AU - Arnold, Paul D.

AU - Assogna, Francesca

AU - Baker, Justin T.

AU - Batistuzzo, Marcelo C.

AU - Benedetti, Francesco

AU - Beucke, Jan C.

AU - Bollettini, Irene

AU - Bose, Anushree

AU - Brem, Silvia

AU - Brennan, Brian P.

AU - Buitelaar, Jan

AU - Calvo, Rosa

AU - Cheng, Yuqi

AU - Cho, Kang Ik K.

AU - Dallaspezia, Sara

AU - Denys, Damiaan

AU - Ely, Benjamin A.

AU - Feusner, Jamie

AU - Fitzgerald, Kate D.

AU - Fouche, Jean Paul

AU - Fridgeirsson, Egill A.

AU - Glahn, David C.

AU - Gruner, Patricia

AU - Gürsel, Deniz A.

AU - Hauser, Tobias U.

AU - Hirano, Yoshiyuki

AU - Hoexter, Marcelo Q.

AU - Hu, Hao

AU - Huyser, Chaim

AU - James, Anthony

AU - Jaspers-Fayer, Fern

AU - Kathmann, Norbert

AU - Kaufmann, Christian

AU - Koch, Kathrin

AU - Kuno, Masaru

AU - Kvale, Gerd

AU - Kwon, Jun Soo

AU - Piras, Fabrizio

AU - Piras, Fabrizio

AU - Spalletta, Gianfranco

AU - Banaj, Nerisa

AU - Ciullo, Valentina

AU - Falini, Andrea

AU - Poletti, Sara

AU - Vecchio, Daniela

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. Methods: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. Results: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = −0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. Conclusions: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.

AB - Background: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. Methods: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. Results: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = −0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. Conclusions: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.

KW - Brain asymmetry

KW - Laterality

KW - Mega-analysis

KW - Obsessive-compulsive disorder

KW - Pallidum

KW - Thalamus

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SN - 0006-3223

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