Abstract
Background: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. Methods: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. Results: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = −0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. Conclusions: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.
| Original language | English |
|---|---|
| Journal | Biological Psychiatry |
| DOIs | |
| Publication status | Published - Jan 1 2019 |
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Keywords
- Brain asymmetry
- Laterality
- Mega-analysis
- Obsessive-compulsive disorder
- Pallidum
- Thalamus
ASJC Scopus subject areas
- Biological Psychiatry
Cite this
Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder : Findings From the ENIGMA Consortium. / ENIGMA-OCD Working Group.
In: Biological Psychiatry, 01.01.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mapping Cortical and Subcortical Asymmetry in Obsessive-Compulsive Disorder
T2 - Findings From the ENIGMA Consortium
AU - ENIGMA-OCD Working Group
AU - Kong, Xiang Zhen
AU - Boedhoe, Premika S.W.
AU - Abe, Yoshinari
AU - Alonso, Pino
AU - Ameis, Stephanie H.
AU - Arnold, Paul D.
AU - Assogna, Francesca
AU - Baker, Justin T.
AU - Batistuzzo, Marcelo C.
AU - Benedetti, Francesco
AU - Beucke, Jan C.
AU - Bollettini, Irene
AU - Bose, Anushree
AU - Brem, Silvia
AU - Brennan, Brian P.
AU - Buitelaar, Jan
AU - Calvo, Rosa
AU - Cheng, Yuqi
AU - Cho, Kang Ik K.
AU - Dallaspezia, Sara
AU - Denys, Damiaan
AU - Ely, Benjamin A.
AU - Feusner, Jamie
AU - Fitzgerald, Kate D.
AU - Fouche, Jean Paul
AU - Fridgeirsson, Egill A.
AU - Glahn, David C.
AU - Gruner, Patricia
AU - Gürsel, Deniz A.
AU - Hauser, Tobias U.
AU - Hirano, Yoshiyuki
AU - Hoexter, Marcelo Q.
AU - Hu, Hao
AU - Huyser, Chaim
AU - James, Anthony
AU - Jaspers-Fayer, Fern
AU - Kathmann, Norbert
AU - Kaufmann, Christian
AU - Koch, Kathrin
AU - Kuno, Masaru
AU - Kvale, Gerd
AU - Kwon, Jun Soo
AU - Piras, Fabrizio
AU - Piras, Fabrizio
AU - Spalletta, Gianfranco
AU - Banaj, Nerisa
AU - Ciullo, Valentina
AU - Falini, Andrea
AU - Poletti, Sara
AU - Vecchio, Daniela
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Background: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. Methods: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. Results: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = −0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. Conclusions: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.
AB - Background: Lateralized dysfunction has been suggested in obsessive-compulsive disorder (OCD). However, it is currently unclear whether OCD is characterized by abnormal patterns of brain structural asymmetry. Here we carried out what is by far the largest study of brain structural asymmetry in OCD. Methods: We studied a collection of 16 pediatric datasets (501 patients with OCD and 439 healthy control subjects), as well as 30 adult datasets (1777 patients and 1654 control subjects) from the OCD Working Group within the ENIGMA (Enhancing Neuro Imaging Genetics through Meta Analysis) Consortium. Asymmetries of the volumes of subcortical structures, and of measures of regional cortical thickness and surface areas, were assessed based on T1-weighted magnetic resonance imaging scans, using harmonized image analysis and quality control protocols. We investigated possible alterations of brain asymmetry in patients with OCD. We also explored potential associations of asymmetry with specific aspects of the disorder and medication status. Results: In the pediatric datasets, the largest case-control differences were observed for volume asymmetry of the thalamus (more leftward; Cohen's d = 0.19) and the pallidum (less leftward; d = −0.21). Additional analyses suggested putative links between these asymmetry patterns and medication status, OCD severity, or anxiety and depression comorbidities. No significant case-control differences were found in the adult datasets. Conclusions: The results suggest subtle changes of the average asymmetry of subcortical structures in pediatric OCD, which are not detectable in adults with the disorder. These findings may reflect altered neurodevelopmental processes in OCD.
KW - Brain asymmetry
KW - Laterality
KW - Mega-analysis
KW - Obsessive-compulsive disorder
KW - Pallidum
KW - Thalamus
UR - http://www.scopus.com/inward/record.url?scp=85066780035&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85066780035&partnerID=8YFLogxK
U2 - 10.1016/j.biopsych.2019.04.022
DO - 10.1016/j.biopsych.2019.04.022
M3 - Article
AN - SCOPUS:85066780035
JO - Biological Psychiatry
JF - Biological Psychiatry
SN - 0006-3223
ER -