Mapping corticocortical structural integrity in schizophrenia and effects of genetic liability

Owen R. Phillips, Keith H. Nuechterlein, Robert F. Asarnow, Kristi A. Clark, Ryan Cabeen, Yaling Yang, Roger P. Woods, Arthur W. Toga, Katherine L. Narr

Research output: Contribution to journalArticlepeer-review


Background: Structural and diffusion tensor imaging studies implicate gray and white matter (WM) abnormalities and disruptions of neural circuitry in schizophrenia. However, the structural integrity of the superficial WM, comprising short-range association (U-fibers) and intracortical axons, has not been investigated in schizophrenia. Methods: High-resolution structural and diffusion tensor images and sophisticated cortical pattern matching methods were used to measure and compare global and local variations in superficial WM fractional anisotropy between schizophrenia patients and their relatives and community comparison subjects and their relatives (n = 150). Results: Compared with control subjects, patients showed reduced superficial WM fractional anisotropy distributed across each hemisphere, particularly in left temporal and bilateral occipital regions (all p

Original languageEnglish
Pages (from-to)680-689
Number of pages10
JournalBiological Psychiatry
Issue number7
Publication statusPublished - Oct 1 2011


  • Diffusion tensor imaging (DTI)
  • fractional anisotropy (FA)
  • magnetic resonance imaging (MRI)
  • short-range association fibers
  • U-fibers
  • white matter (WM)

ASJC Scopus subject areas

  • Biological Psychiatry


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