Mapping critical cortical hubs and white matter pathways by direct electrical stimulation: an original functional atlas of the human brain

S. Sarubbo, M. Tate, A. De Benedictis, S. Merler, S. Moritz-Gasser, G. Herbet, H. Duffau

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: The structural and functional organization of brain networks subserving basic daily activities (i.e. language, visuo-spatial cognition, movement, semantics, etc.) are not completely understood to date. Here, we report the first probabilistic cortical and subcortical atlas of critical structures mediating human brain functions based on direct electrical stimulation (DES), a well-validated tool for the exploration of cerebral processing and for performing safe surgical interventions in eloquent areas. Methods: We collected 1162 cortical and 659 subcortical DES responses during testing of 16 functional domains in 256 patients undergoing awake surgery. Spatial coordinates for each functional response were calculated, and probability distributions for the entire patient cohort were mapped onto a standardized three-dimensional brain template using a multinomial statistical analysis. In addition, matching analyses were performed against prior established anatomy-based cortical and white matter (WM) atlases. Results: The probabilistic maps for each functional domain were provided. The topographical analysis demonstrated a wide spatial distribution of cortical functional responses, while subcortical responses were more restricted, localizing to known WM pathways. These DES-derived data showed reliable matching with existing cortical and WM atlases as well as recent neuroimaging and neurophysiological data. Conclusions: We present the first integrated and comprehensive cortical-subcortical atlas of structures essential for humans’ neural functions based on highly-specific DES mapping during real-time neuropsychological testing. This novel atlas can serve as a complementary tool for neuroscientists, along with data obtained from other modalities, to improve and refine our understanding of the functional anatomy of critical brain networks. © 2019
Original languageEnglish
JournalNeuroImage
Volume205
DOIs
Publication statusPublished - 2020

Keywords

  • Atlas
  • Brain functions
  • Brain mapping
  • Direct electrical stimulation
  • Subcortical
  • White matter
  • adult
  • article
  • brain mapping
  • cohort analysis
  • controlled study
  • electrostimulation
  • female
  • functional anatomy
  • human
  • major clinical study
  • male
  • nerve cell network
  • neuroimaging
  • neuropsychological test
  • neuroscientist
  • probability
  • wakefulness
  • white matter
  • book
  • brain cortex
  • diagnostic imaging
  • nerve tract
  • neurosurgery
  • nuclear magnetic resonance imaging
  • physiology
  • preoperative period
  • procedures
  • Adult
  • Atlases as Topic
  • Brain Mapping
  • Cerebral Cortex
  • Electric Stimulation
  • Humans
  • Magnetic Resonance Imaging
  • Neural Pathways
  • Neurosurgical Procedures
  • Preoperative Period
  • White Matter

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