TY - JOUR
T1 - Mapping distributed sources of cortical rhythms in mild Alzheimer's disease. A multicentric EEG study
AU - Babiloni, Claudio
AU - Binetti, Giuliano
AU - Cassetta, Emanuele
AU - Cerboneschi, Daniele
AU - Dal Forno, Gloria
AU - Del Percio, Claudio
AU - Ferreri, Florinda
AU - Ferri, Raffaele
AU - Lanuzza, Bartolo
AU - Miniussi, Carlo
AU - Moretti, Davide V.
AU - Nobili, Flavio
AU - Pascual-Marqui, Roberto D.
AU - Rodriguez, Guido
AU - Romani, Gian Luca
AU - Salinari, Serenella
AU - Tecchio, Franca
AU - Vitali, Paolo
AU - Zanetti, Orazio
AU - Zappasodi, Filippo
AU - Rossini, Paolo M.
PY - 2004/5
Y1 - 2004/5
N2 - The study aimed at mapping (i) the distributed electroencephalographic (EEG) sources specific for mild Alzheimer's disease (AD) compared to vascular dementia (VaD) or normal elderly people (Nold) and (ii) the distributed EEG sources sensitive to the mild AD at different stages of severity. Resting EEG (10-20 electrode montage) was recorded from 48 mild AD, 20 VaD, and 38 Nold subjects. Both AD and VaD patients had 24-17 of mini mental state examination (MMSE). EEG rhythms were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). Cortical EEG sources were modeled by low resolution brain electromagnetic tomography (LORETA). Regarding issue i, there was a decline of central, parietal, temporal, and limbic alpha 1 (low alpha) sources specific for mild AD group with respect to Nold and VaD groups. Furthermore, occipital alpha 1 sources showed a strong decline in mild AD compared to VaD group. Finally, distributed theta sources were largely abnormal in VaD but not in mild AD group. Regarding issue ii, there was a lower power of occipital alpha 1 sources in mild AD subgroup having more severe disease. Compared to previous field studies, this was the first investigation that illustrated the power spectrum profiles at the level of cortical (macroregions) EEG sources in mild AD patients having different severity of the disease with respect to VaD and normal subjects. Future studies should evaluate the clinical usefulness of this approach in early differential diagnosis, disease staging, and therapy monitoring.
AB - The study aimed at mapping (i) the distributed electroencephalographic (EEG) sources specific for mild Alzheimer's disease (AD) compared to vascular dementia (VaD) or normal elderly people (Nold) and (ii) the distributed EEG sources sensitive to the mild AD at different stages of severity. Resting EEG (10-20 electrode montage) was recorded from 48 mild AD, 20 VaD, and 38 Nold subjects. Both AD and VaD patients had 24-17 of mini mental state examination (MMSE). EEG rhythms were delta (2-4 Hz), theta (4-8 Hz), alpha 1 (8-10.5 Hz), alpha 2 (10.5-13 Hz), beta 1 (13-20 Hz), and beta 2 (20-30 Hz). Cortical EEG sources were modeled by low resolution brain electromagnetic tomography (LORETA). Regarding issue i, there was a decline of central, parietal, temporal, and limbic alpha 1 (low alpha) sources specific for mild AD group with respect to Nold and VaD groups. Furthermore, occipital alpha 1 sources showed a strong decline in mild AD compared to VaD group. Finally, distributed theta sources were largely abnormal in VaD but not in mild AD group. Regarding issue ii, there was a lower power of occipital alpha 1 sources in mild AD subgroup having more severe disease. Compared to previous field studies, this was the first investigation that illustrated the power spectrum profiles at the level of cortical (macroregions) EEG sources in mild AD patients having different severity of the disease with respect to VaD and normal subjects. Future studies should evaluate the clinical usefulness of this approach in early differential diagnosis, disease staging, and therapy monitoring.
KW - Alpha rhythm
KW - Electroencephalography (EEG)
KW - Low resolution brain electromagnetic tomography (LORETA)
KW - Mild Alzheimer's disease (mild AD)
KW - Vascular dementia (VaD)
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UR - http://www.scopus.com/inward/citedby.url?scp=11144355811&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2003.09.028
DO - 10.1016/j.neuroimage.2003.09.028
M3 - Article
C2 - 15109997
AN - SCOPUS:11144355811
VL - 22
SP - 57
EP - 67
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
IS - 1
ER -