Mapping entrained brain oscillations during transcranial alternating current stimulation (tACS)

Matthias Witkowski, Eliana Garcia-Cossio, Bankim S. Chander, Christoph Braun, Niels Birbaumer, Stephen E. Robinson, Surjo R. Soekadar

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Transcranial alternating current stimulation (tACS), a non-invasive and well-tolerated form of electric brain stimulation, can influence perception, memory, as well as motor and cognitive function. While the exact underlying neurophysiological mechanisms are unknown, the effects of tACS are mainly attributed to frequency-specific entrainment of endogenous brain oscillations in brain areas close to the stimulation electrodes, and modulation of spike timing dependent plasticity reflected in gamma band oscillatory responses. tACS-related electromagnetic stimulator artifacts, however, impede investigation of these neurophysiological mechanisms. Here we introduce a novel approach combining amplitude-modulated tACS during whole-head magnetoencephalography (MEG) allowing for artifact-free source reconstruction and precise mapping of entrained brain oscillations underneath the stimulator electrodes. Using this approach, we show that reliable reconstruction of neuromagnetic low- and high-frequency oscillations including high gamma band activity in stimulated cortical areas is feasible opening a new window to unveil the mechanisms underlying the effects of stimulation protocols that entrain brain oscillatory activity.

Original languageEnglish
JournalNeuroImage
DOIs
Publication statusAccepted/In press - 2015

Fingerprint

Brain Mapping
Brain
Artifacts
Electrodes
Magnetoencephalography
Electromagnetic Phenomena
Cognition
Electric Stimulation
Head
Transcranial Direct Current Stimulation

Keywords

  • Entrainment
  • Neuromagnetic brain oscillations
  • Transcranial alternating current stimulation
  • Whole-head magnetoencephalography

ASJC Scopus subject areas

  • Cognitive Neuroscience
  • Neurology

Cite this

Witkowski, M., Garcia-Cossio, E., Chander, B. S., Braun, C., Birbaumer, N., Robinson, S. E., & Soekadar, S. R. (Accepted/In press). Mapping entrained brain oscillations during transcranial alternating current stimulation (tACS). NeuroImage. https://doi.org/10.1016/j.neuroimage.2015.10.024

Mapping entrained brain oscillations during transcranial alternating current stimulation (tACS). / Witkowski, Matthias; Garcia-Cossio, Eliana; Chander, Bankim S.; Braun, Christoph; Birbaumer, Niels; Robinson, Stephen E.; Soekadar, Surjo R.

In: NeuroImage, 2015.

Research output: Contribution to journalArticle

Witkowski, M, Garcia-Cossio, E, Chander, BS, Braun, C, Birbaumer, N, Robinson, SE & Soekadar, SR 2015, 'Mapping entrained brain oscillations during transcranial alternating current stimulation (tACS)', NeuroImage. https://doi.org/10.1016/j.neuroimage.2015.10.024
Witkowski, Matthias ; Garcia-Cossio, Eliana ; Chander, Bankim S. ; Braun, Christoph ; Birbaumer, Niels ; Robinson, Stephen E. ; Soekadar, Surjo R. / Mapping entrained brain oscillations during transcranial alternating current stimulation (tACS). In: NeuroImage. 2015.
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