Mapping fundamental life elements in papillary thyroid carcinoma tissue

L. Merolle, M. Ragazzi, A. Gianoncelli, M. Altissimo, A. Ciarrocchi, D. E. Bedolla, C. Marraccini, R. Baricchi, T. A. Pertinhez

Research output: Contribution to journalArticle

Abstract

Well-differentiated papillary thyroid carcinomas (PTCs) are the most common type of thyroid cancer. Thyroid function depends on the presence of certain trace elements necessary for both the synthesis and the metabolism of thyroid hormones. We conducted an observational translational study on formalin fixed paraffin embedded thyroid tissue slices collected from five patients who underwent surgical resection of thyroid gland after thyroid cancer diagnosis. A synchrotron-based XRF set up was used to map the distribution of oxygen, sodium, aluminum, selenium and magnesium in PTC sections. These experiments were performed at the TwinMic beamline (Elettra - Sincrotrone Trieste, Trieste, Italy). Our results show that Mg levels in PTC tissues are significantly higher than in the control ones. The results seem to provide highly valuable information suggesting that Mg may play a role in the development and metabolic process of PTC.

Original languageEnglish
Article numberC05018
JournalJournal of Instrumentation
Volume13
Issue number5
DOIs
Publication statusPublished - May 24 2018

Fingerprint

Cancer
cancer
Tissue
Magnesium
Selenium
Hormones
Trace elements
Synchrotrons
Formaldehyde
Metabolism
Slice
Sodium
Paraffins
Aluminum
Oxygen
Trace
Synthesis
Necessary
thyroid gland
Experiment

Keywords

  • Inspection with x-rays
  • Multi-modality systems
  • X-ray fluorescence (XRF) systems

ASJC Scopus subject areas

  • Instrumentation
  • Mathematical Physics

Cite this

Merolle, L., Ragazzi, M., Gianoncelli, A., Altissimo, M., Ciarrocchi, A., Bedolla, D. E., ... Pertinhez, T. A. (2018). Mapping fundamental life elements in papillary thyroid carcinoma tissue. Journal of Instrumentation, 13(5), [C05018]. https://doi.org/10.1088/1748-0221/13/05/C05018

Mapping fundamental life elements in papillary thyroid carcinoma tissue. / Merolle, L.; Ragazzi, M.; Gianoncelli, A.; Altissimo, M.; Ciarrocchi, A.; Bedolla, D. E.; Marraccini, C.; Baricchi, R.; Pertinhez, T. A.

In: Journal of Instrumentation, Vol. 13, No. 5, C05018, 24.05.2018.

Research output: Contribution to journalArticle

Merolle, L, Ragazzi, M, Gianoncelli, A, Altissimo, M, Ciarrocchi, A, Bedolla, DE, Marraccini, C, Baricchi, R & Pertinhez, TA 2018, 'Mapping fundamental life elements in papillary thyroid carcinoma tissue', Journal of Instrumentation, vol. 13, no. 5, C05018. https://doi.org/10.1088/1748-0221/13/05/C05018
Merolle, L. ; Ragazzi, M. ; Gianoncelli, A. ; Altissimo, M. ; Ciarrocchi, A. ; Bedolla, D. E. ; Marraccini, C. ; Baricchi, R. ; Pertinhez, T. A. / Mapping fundamental life elements in papillary thyroid carcinoma tissue. In: Journal of Instrumentation. 2018 ; Vol. 13, No. 5.
@article{079f94d91a4d4fb9b27e5cefdcdfc71d,
title = "Mapping fundamental life elements in papillary thyroid carcinoma tissue",
abstract = "Well-differentiated papillary thyroid carcinomas (PTCs) are the most common type of thyroid cancer. Thyroid function depends on the presence of certain trace elements necessary for both the synthesis and the metabolism of thyroid hormones. We conducted an observational translational study on formalin fixed paraffin embedded thyroid tissue slices collected from five patients who underwent surgical resection of thyroid gland after thyroid cancer diagnosis. A synchrotron-based XRF set up was used to map the distribution of oxygen, sodium, aluminum, selenium and magnesium in PTC sections. These experiments were performed at the TwinMic beamline (Elettra - Sincrotrone Trieste, Trieste, Italy). Our results show that Mg levels in PTC tissues are significantly higher than in the control ones. The results seem to provide highly valuable information suggesting that Mg may play a role in the development and metabolic process of PTC.",
keywords = "Inspection with x-rays, Multi-modality systems, X-ray fluorescence (XRF) systems",
author = "L. Merolle and M. Ragazzi and A. Gianoncelli and M. Altissimo and A. Ciarrocchi and Bedolla, {D. E.} and C. Marraccini and R. Baricchi and Pertinhez, {T. A.}",
year = "2018",
month = "5",
day = "24",
doi = "10.1088/1748-0221/13/05/C05018",
language = "English",
volume = "13",
journal = "Journal of Instrumentation",
issn = "1748-0221",
publisher = "IOP Publishing Ltd.",
number = "5",

}

TY - JOUR

T1 - Mapping fundamental life elements in papillary thyroid carcinoma tissue

AU - Merolle, L.

AU - Ragazzi, M.

AU - Gianoncelli, A.

AU - Altissimo, M.

AU - Ciarrocchi, A.

AU - Bedolla, D. E.

AU - Marraccini, C.

AU - Baricchi, R.

AU - Pertinhez, T. A.

PY - 2018/5/24

Y1 - 2018/5/24

N2 - Well-differentiated papillary thyroid carcinomas (PTCs) are the most common type of thyroid cancer. Thyroid function depends on the presence of certain trace elements necessary for both the synthesis and the metabolism of thyroid hormones. We conducted an observational translational study on formalin fixed paraffin embedded thyroid tissue slices collected from five patients who underwent surgical resection of thyroid gland after thyroid cancer diagnosis. A synchrotron-based XRF set up was used to map the distribution of oxygen, sodium, aluminum, selenium and magnesium in PTC sections. These experiments were performed at the TwinMic beamline (Elettra - Sincrotrone Trieste, Trieste, Italy). Our results show that Mg levels in PTC tissues are significantly higher than in the control ones. The results seem to provide highly valuable information suggesting that Mg may play a role in the development and metabolic process of PTC.

AB - Well-differentiated papillary thyroid carcinomas (PTCs) are the most common type of thyroid cancer. Thyroid function depends on the presence of certain trace elements necessary for both the synthesis and the metabolism of thyroid hormones. We conducted an observational translational study on formalin fixed paraffin embedded thyroid tissue slices collected from five patients who underwent surgical resection of thyroid gland after thyroid cancer diagnosis. A synchrotron-based XRF set up was used to map the distribution of oxygen, sodium, aluminum, selenium and magnesium in PTC sections. These experiments were performed at the TwinMic beamline (Elettra - Sincrotrone Trieste, Trieste, Italy). Our results show that Mg levels in PTC tissues are significantly higher than in the control ones. The results seem to provide highly valuable information suggesting that Mg may play a role in the development and metabolic process of PTC.

KW - Inspection with x-rays

KW - Multi-modality systems

KW - X-ray fluorescence (XRF) systems

UR - http://www.scopus.com/inward/record.url?scp=85048114326&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048114326&partnerID=8YFLogxK

U2 - 10.1088/1748-0221/13/05/C05018

DO - 10.1088/1748-0221/13/05/C05018

M3 - Article

AN - SCOPUS:85048114326

VL - 13

JO - Journal of Instrumentation

JF - Journal of Instrumentation

SN - 1748-0221

IS - 5

M1 - C05018

ER -