Mapping local hippocampal changes in Alzheimer's disease and normal ageing with MRI at 3 Tesla

Giovanni B. Frisoni, Rossana Ganzola, Elisa Canu, Udo Rüb, Francesca B. Pizzini, Franco Alessandrini, Giada Zoccatelli, Alberto Beltramello, Carlo Caltagirone, Paul M. Thompson

Research output: Contribution to journalArticlepeer-review


Histological studies have suggested differing involvement of the hippocampal subfields in ageing and in Alzheimer's disease. The aim of this study was to assess in vivo local hippocampal changes in ageing and Alzheimer's disease based on high resolution MRI at 3 Tesla. T1-weighted images were acquired from 19 Alzheimer's disease patients [age 76 ± 6 years, three males, Mini-Mental State Examination 13 ± 4] and 19 controls (age 74 ± 5 years, 11 males, Mini-Mental State Examination 29 ± 1). The hippocampal formation was isolated by manual tracing. Radial atrophy mapping was used to assess group differences and correlations by averaging hippocampal shapes across subjects using 3D parametric surface mesh models. Percentage difference, Pearson's r, and significance maps were produced. Hippocampal volumes were inversely correlated with age in older healthy controls (r = 0.56 and 0.6 to the right and left, respectively, P <0.05, corresponding to 14% lower volume for every 10 years of older age from ages 65 to 85 years). Ageing-associated atrophy mapped to medial and lateral areas of the tail and body corresponding to the CA1 subfield and ventral areas of the head corresponding to the presubiculum. Significantly increased volume with older age mapped to a few small spots mainly located to the CA1 sector of the right hippocampus. Volumes were 35% and 30% smaller in Alzheimer's disease patients to the right and left (P <0.0005). Alzheimer's disease-associated atrophy mapped not only to CA1 areas of the body and tail corresponding to those also associated with age, but also to dorsal CA1 areas of the head unaffected by age. Regions corresponding to the CA2-3 fields were relatively spared in both ageing and Alzheimer's disease. Hippocampal atrophy in Alzheimer's disease maps to areas in the body and tail that partly overlap those affected by normal ageing. Specific areas in the anterior and dorsal CA1 subfield involved in Alzheimer's disease were not in normal ageing. These patterns might relate to differential neural systems involved in Alzheimer's disease and ageing.

Original languageEnglish
Pages (from-to)3266-3276
Number of pages11
Issue number12
Publication statusPublished - Dec 2008


  • 3D-shape
  • Ageing
  • Alzheimer's disease
  • Hippocampus
  • Magnetic resonance

ASJC Scopus subject areas

  • Clinical Neurology


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