Mapping of brain tumor metabolites with proton MR spectroscopic imaging: Clinical relevance

Michael J. Fulham, Alberto Bizzi, Mark J. Dietz, Henry H L Shih, Ramesh Raman, Geoffrey S. Sobering, Joseph A. Frank, Andrew J. Dwyer, Jeffry R. Alger, Giovanni Di Chiro

Research output: Contribution to journalArticle

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Abstract

Brain tumor metabolism was studied with hydrogen-1 magnetic resonance spectroscopy and positron emission tomography with fluorine-18 fluorodeoxyglucose in 50 patients. N-acetylaspartate (NAA) was generally decreased in tumors and radiation necrosis but was somewhat preserved at neoplasm margins. Choline was increased in most solid tumors. Solid high-grade gliomas had higher normalized choline values than did solid low-grade gliomas (P <.02), but the normalized choline value was not a discriminator of tumor grade, since necrotic high-grade lesions had reduced choline values. Serial studies in one case showed an increase in choline as the glioma underwent malignant degeneration. Choline values were lower in chronic radiation necrosis than in solid anaplastic tumors (P <.001). In two cases studied before and after treatment, clinical improvement and a reduction in choline followed therapy. Lactate is more likely to be found in high-grade gliomas, but its presence is not a reliable indicator of malignancy.

Original languageEnglish
Pages (from-to)675-686
Number of pages12
JournalRadiology
Volume185
Issue number3
Publication statusPublished - Dec 1992

Fingerprint

Choline
Brain Neoplasms
Protons
Glioma
Neoplasms
Necrosis
Radiation
Fluorodeoxyglucose F18
Positron-Emission Tomography
Hydrogen
Lactic Acid
Magnetic Resonance Spectroscopy
Therapeutics

Keywords

  • Brain neoplasms, CT, 13.1211
  • Brain neoplasms, MR, 13.1214
  • Brain neoplasms, therapeutic radiology, 13.47
  • Brain, effects of irradiation on, 13.47
  • Emission CT, 13.1211
  • Magnetic resonance (MR), spectroscopy, 13.1219

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Fulham, M. J., Bizzi, A., Dietz, M. J., Shih, H. H. L., Raman, R., Sobering, G. S., ... Di Chiro, G. (1992). Mapping of brain tumor metabolites with proton MR spectroscopic imaging: Clinical relevance. Radiology, 185(3), 675-686.

Mapping of brain tumor metabolites with proton MR spectroscopic imaging : Clinical relevance. / Fulham, Michael J.; Bizzi, Alberto; Dietz, Mark J.; Shih, Henry H L; Raman, Ramesh; Sobering, Geoffrey S.; Frank, Joseph A.; Dwyer, Andrew J.; Alger, Jeffry R.; Di Chiro, Giovanni.

In: Radiology, Vol. 185, No. 3, 12.1992, p. 675-686.

Research output: Contribution to journalArticle

Fulham, MJ, Bizzi, A, Dietz, MJ, Shih, HHL, Raman, R, Sobering, GS, Frank, JA, Dwyer, AJ, Alger, JR & Di Chiro, G 1992, 'Mapping of brain tumor metabolites with proton MR spectroscopic imaging: Clinical relevance', Radiology, vol. 185, no. 3, pp. 675-686.
Fulham MJ, Bizzi A, Dietz MJ, Shih HHL, Raman R, Sobering GS et al. Mapping of brain tumor metabolites with proton MR spectroscopic imaging: Clinical relevance. Radiology. 1992 Dec;185(3):675-686.
Fulham, Michael J. ; Bizzi, Alberto ; Dietz, Mark J. ; Shih, Henry H L ; Raman, Ramesh ; Sobering, Geoffrey S. ; Frank, Joseph A. ; Dwyer, Andrew J. ; Alger, Jeffry R. ; Di Chiro, Giovanni. / Mapping of brain tumor metabolites with proton MR spectroscopic imaging : Clinical relevance. In: Radiology. 1992 ; Vol. 185, No. 3. pp. 675-686.
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