Mapping of functional changes associated with administration of substances of abuse in the rat

Francesco E. Pontieri, Alessandro Zocchi, Francesco Orzi

Research output: Contribution to journalArticlepeer-review

Abstract

The [14C]2-deoxyglucose method allows us to investigate whether a drug affects cerebral functional activity in selected brain regions or along discrete neural pathways. Employment of the method in laboratory animals has shown that substances of abuse produce a wide variety of cerebral functional changes which depend upon a number of different variables including the kind of substance, the dose, the modality of administration, and the context. In spite of such a variability, different substances of abuse, when injected in a rat at doses, or with modalities effective in inducing self-administration, have in common the property of selectively modifying glucose utilization of the nucleus accumbens, in particular in the shell portion. It is likely that the change reflects a functional change of a neural circuitry which mediates motivational properties associated with addiction.

Original languageEnglish
Pages (from-to)311-326
Number of pages16
JournalFunctional Neurology
Volume13
Issue number4
Publication statusPublished - 1998

Keywords

  • Deoxyglucose
  • Dopamine
  • Glucose utilization
  • Nucleus accumbens
  • Substances of abuse

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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