Mapping of human WHN gene in a 17q11.2 YAC contig and identification of an intragenic STR

L. Corrado; P. Colapietro; L. Larizza; P. Riva

doi:10.1006/mcpr.1999.0237

Mapping of human WHN gene in a 17q11.2 YAC contig and identification of an intragenic STR

L. Corrado, P. Colapietro, L. Larizza, P. Riva

Fondazione Istituto Auxologico Italiano

Research output: Contribution to journal › Article › peer-review

Abstract

The recently isolated human WHN gene has been previously assigned to chromosome 17q11-12 using radiation hybrids. In this study, we constructed a YAC contig covering 17q11.2 between crystallinBA1 and neurofibromatosis 1 genes. By ordering known and novel markers, we determined the position of the WHN gene, and of the closely linked retinal 4 and sodium/dicarboxylate cotransporter genes. We also identified a new mononucleotide polymorphism contained within the untranslated exon 1 of the WHN gene, which may be useful for linkage and LOH studies.

Original language	English
Pages (from-to)	199-202
Number of pages	4
Journal	Molecular and Cellular Probes
Volume	13
Issue number	3
DOIs	https://doi.org/10.1006/mcpr.1999.0237
Publication status	Published - Jun 1999

Keywords

Human WHN gene
Retinal 4 gene
Sodium/dicarboxylate cotransporter gene
STR
YAC contig

ASJC Scopus subject areas

Cell Biology
Molecular Biology

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10.1006/mcpr.1999.0237

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AU - Corrado, L.

AU - Colapietro, P.

AU - Larizza, L.

AU - Riva, P.

PY - 1999/6

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AB - The recently isolated human WHN gene has been previously assigned to chromosome 17q11-12 using radiation hybrids. In this study, we constructed a YAC contig covering 17q11.2 between crystallinBA1 and neurofibromatosis 1 genes. By ordering known and novel markers, we determined the position of the WHN gene, and of the closely linked retinal 4 and sodium/dicarboxylate cotransporter genes. We also identified a new mononucleotide polymorphism contained within the untranslated exon 1 of the WHN gene, which may be useful for linkage and LOH studies.

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KW - Sodium/dicarboxylate cotransporter gene

KW - STR

KW - YAC contig

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Mapping of human WHN gene in a 17q11.2 YAC contig and identification of an intragenic STR

Abstract

Keywords

ASJC Scopus subject areas

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