Mapping of motor cortical reorganization after stroke: A brain simulation study with focal magnetic pulses

Raimondo Traversa, Paola Cicinelli, Andrea Bassi, Paolo Maria Rossini, Giorgio Bernardi

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Purpose: Focal transcranial magnetic stimulation (TCS) is used for noninvasive and painless mapping of the somatotopical organization of the motor cortex. TCS mapping of motor cortical output to the abductor digiti minimi (ADM) muscle was followed up in monohemispheric stroke patients by evaluating motor evoked potentials (MEPs). This approach allowed noninvasive investigation of the functional reorganization of hand motor areas. Methods: Motor maps were constructed for 15 subacute stroke patients about 2 months from the ictus by recording MEPs from the ADM muscle via focal TCS in the affected hemisphere (AH) and unaffected hemisphere (UH) at the beginning of (T1) and after 8 to 10 weeks of neurorehabilitation (T2). Barthel Index and Canadian Neurological Scale scores were evaluated as well. An age-sex matched group of 15 healthy control subjects was enrolled to establish normative data. Results: MEP excitability threshold was significantly higher in the AH of stroke patients than in normal subjects and in the UH (P

Original languageEnglish
Pages (from-to)110-117
Number of pages8
JournalStroke
Volume28
Issue number1
Publication statusPublished - Jan 1997

Keywords

  • cerebrovascular disorders
  • motor activity
  • neuronal plasticity
  • stroke outcome

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Neuroscience(all)

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