Mapping of the mouse Tdgf1 gene and Tdgf pseudogenes

G. Liguori, L. De Gregorio, M. Tucci, C. T. Lago, A. Barra, T. A. Dragani, M. Persico

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Teratocarcinoma-derived growth factor-1 (Tdgf1), a member of the 'EGF family' of growth factors, is expressed during mouse gastrulation in the forming mesoderm and later in the truncus arteriosus of the developing heart. In humans, TDGF1 is highly expressed in germ cell tumors and in colon and mammary carcinomas. In mouse, one gene (Tdgf1) and two pseudogenes (Tdgf1-ps1 and Tdgf1-ps2) have been isolated and characterized. Tdgf1 corresponds to the gene expressed in F9 teratocarcinoma cells. Tdgf1-ps1 and Tdgf1-ps2 are two intronless sequences with all the characteristics of retroposons. In the present paper, we assign the chromosomal location for Tdgf1, Tdgf1-ps1, and Tdgf1-ps2 sequences to Chromosomes (Chrs) 9, 16, and 17, respectively. Two previously described mouse mutants, scant hair (sch) and fur deficient (fd), map near the Tdgf1 gene. Analysis of their DNA coding region provided no evidence that Tdgf1 could be the responsible gene for these phenotypes. Finally, analysis of the DNA from several Mus musculus strains and from Mus spretus mice revealed a highly variable restriction pattern and the absence of the Tdgf1-ps1 genomic sequence from the Mus spretus genome.

Original languageEnglish
Pages (from-to)502-505
Number of pages4
JournalMammalian Genome
Volume8
Issue number7
DOIs
Publication statusPublished - Jul 1997

Fingerprint

Teratocarcinoma
Pseudogenes
Intercellular Signaling Peptides and Proteins
Genes
Mouse Tdgf1 protein
Truncus Arteriosus
Chromosomes, Human, Pair 16
Gastrulation
Retroelements
Chromosomes, Human, Pair 9
Chromosomes, Human, Pair 17
Germ Cell and Embryonal Neoplasms
DNA
Mesoderm
Epidermal Growth Factor

ASJC Scopus subject areas

  • Genetics

Cite this

Liguori, G., De Gregorio, L., Tucci, M., Lago, C. T., Barra, A., Dragani, T. A., & Persico, M. (1997). Mapping of the mouse Tdgf1 gene and Tdgf pseudogenes. Mammalian Genome, 8(7), 502-505. https://doi.org/10.1007/s003359900484

Mapping of the mouse Tdgf1 gene and Tdgf pseudogenes. / Liguori, G.; De Gregorio, L.; Tucci, M.; Lago, C. T.; Barra, A.; Dragani, T. A.; Persico, M.

In: Mammalian Genome, Vol. 8, No. 7, 07.1997, p. 502-505.

Research output: Contribution to journalArticle

Liguori, G, De Gregorio, L, Tucci, M, Lago, CT, Barra, A, Dragani, TA & Persico, M 1997, 'Mapping of the mouse Tdgf1 gene and Tdgf pseudogenes', Mammalian Genome, vol. 8, no. 7, pp. 502-505. https://doi.org/10.1007/s003359900484
Liguori G, De Gregorio L, Tucci M, Lago CT, Barra A, Dragani TA et al. Mapping of the mouse Tdgf1 gene and Tdgf pseudogenes. Mammalian Genome. 1997 Jul;8(7):502-505. https://doi.org/10.1007/s003359900484
Liguori, G. ; De Gregorio, L. ; Tucci, M. ; Lago, C. T. ; Barra, A. ; Dragani, T. A. ; Persico, M. / Mapping of the mouse Tdgf1 gene and Tdgf pseudogenes. In: Mammalian Genome. 1997 ; Vol. 8, No. 7. pp. 502-505.
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