Mapping on Human and Mouse Chromosomes of the Gene for the β-Galactoside-Binding Protein, an Autocrine-Negative Growth Factor

Antonio Baldini; Thomas Gress; Ketan Patel; Rosella Muresu; Lorenzo Chiariotti; Penny Williamson; Yvonne Boyd; Ida Casciano; Valerie Wells; Carmelo B. Bruni; Livio Mallucci; Marcello Siniscalco

doi:10.1006/geno.1993.1039

Mapping on Human and Mouse Chromosomes of the Gene for the β-Galactoside-Binding Protein, an Autocrine-Negative Growth Factor

Antonio Baldini, Thomas Gress, Ketan Patel, Rosella Muresu, Lorenzo Chiariotti, Penny Williamson, Yvonne Boyd, Ida Casciano, Valerie Wells, Carmelo B. Bruni, Livio Mallucci, Marcello Siniscalco

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Research output: Contribution to journal › Article

Abstract

The structural gene for β-galactoside-binding protein (Lgals-1), a cell growth regulatory molecule and cystostatic factor, is assigned to the E-region of mouse chromosome 15 and to the region q12-q13.1 of human chromosome 22. The evolutionary conservation of these two regions has been previously suggested from comparative mapping of several loci. These include the murine SIS oncogene (Pdgfb) and its human homolog, the platelet-derived growth factor-β polypeptide, PDGFB. The findings presented here extend the genetic homology of the two regions.

Original language	English
Pages (from-to)	216-218
Number of pages	3
Journal	Genomics
Volume	15
Issue number	1
DOIs	https://doi.org/10.1006/geno.1993.1039
Publication status	Published - Jan 1993

ASJC Scopus subject areas

Genetics

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Baldini, A., Gress, T., Patel, K., Muresu, R., Chiariotti, L., Williamson, P., Boyd, Y., Casciano, I., Wells, V., Bruni, C. B., Mallucci, L., & Siniscalco, M. (1993). Mapping on Human and Mouse Chromosomes of the Gene for the β-Galactoside-Binding Protein, an Autocrine-Negative Growth Factor. Genomics, 15(1), 216-218. https://doi.org/10.1006/geno.1993.1039

Mapping on Human and Mouse Chromosomes of the Gene for the β-Galactoside-Binding Protein, an Autocrine-Negative Growth Factor. / Baldini, Antonio; Gress, Thomas; Patel, Ketan; Muresu, Rosella; Chiariotti, Lorenzo; Williamson, Penny; Boyd, Yvonne; Casciano, Ida; Wells, Valerie; Bruni, Carmelo B.; Mallucci, Livio; Siniscalco, Marcello.

In: Genomics, Vol. 15, No. 1, 01.1993, p. 216-218.

Research output: Contribution to journal › Article

Baldini, Antonio ; Gress, Thomas ; Patel, Ketan ; Muresu, Rosella ; Chiariotti, Lorenzo ; Williamson, Penny ; Boyd, Yvonne ; Casciano, Ida ; Wells, Valerie ; Bruni, Carmelo B. ; Mallucci, Livio ; Siniscalco, Marcello. / Mapping on Human and Mouse Chromosomes of the Gene for the β-Galactoside-Binding Protein, an Autocrine-Negative Growth Factor. In: Genomics. 1993 ; Vol. 15, No. 1. pp. 216-218.

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abstract = "The structural gene for β-galactoside-binding protein (Lgals-1), a cell growth regulatory molecule and cystostatic factor, is assigned to the E-region of mouse chromosome 15 and to the region q12-q13.1 of human chromosome 22. The evolutionary conservation of these two regions has been previously suggested from comparative mapping of several loci. These include the murine SIS oncogene (Pdgfb) and its human homolog, the platelet-derived growth factor-β polypeptide, PDGFB. The findings presented here extend the genetic homology of the two regions.",

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