Mapping on Human and Mouse Chromosomes of the Gene for the β-Galactoside-Binding Protein, an Autocrine-Negative Growth Factor

Antonio Baldini, Thomas Gress, Ketan Patel, Rosella Muresu, Lorenzo Chiariotti, Penny Williamson, Yvonne Boyd, Ida Casciano, Valerie Wells, Carmelo B. Bruni, Livio Mallucci, Marcello Siniscalco

Research output: Contribution to journalArticle

Abstract

The structural gene for β-galactoside-binding protein (Lgals-1), a cell growth regulatory molecule and cystostatic factor, is assigned to the E-region of mouse chromosome 15 and to the region q12-q13.1 of human chromosome 22. The evolutionary conservation of these two regions has been previously suggested from comparative mapping of several loci. These include the murine SIS oncogene (Pdgfb) and its human homolog, the platelet-derived growth factor-β polypeptide, PDGFB. The findings presented here extend the genetic homology of the two regions.

Original languageEnglish
Pages (from-to)216-218
Number of pages3
JournalGenomics
Volume15
Issue number1
DOIs
Publication statusPublished - Jan 1993

ASJC Scopus subject areas

  • Genetics

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    Baldini, A., Gress, T., Patel, K., Muresu, R., Chiariotti, L., Williamson, P., Boyd, Y., Casciano, I., Wells, V., Bruni, C. B., Mallucci, L., & Siniscalco, M. (1993). Mapping on Human and Mouse Chromosomes of the Gene for the β-Galactoside-Binding Protein, an Autocrine-Negative Growth Factor. Genomics, 15(1), 216-218. https://doi.org/10.1006/geno.1993.1039