Abstract
Previous studies suggest that in Alzheimer's disease (AD) the Apolipoprotein E (APOE) ε4 allele is associated with greater vulnerability of medial temporal lobe structures. However, less is known about its effect on the whole cortical mantle. Here we aimed to identify APOE-related patterns of cortical atrophy in AD using an advanced computational anatomy technique. We studied 15 AD patients carriers (ε4+, age: 72 ± 10 SD years, MMSE: 20 ± 3 SD) and 14 non-carriers (ε4-, age: 69 ± 9, MMSE: 20 ± 5) of the ε4 allele and compared them to 29 age-and-sex matched controls (age: 70 ± 9, MMSE: 28 ± 1). Each subject underwent a clinical evaluation, a neuropsychological battery, and high-resolution MRI. UCLA's cortical pattern matching technique was used to identify regions of local cortical atrophy. ε4+ and ε4- patients showed similar performance on neuropsychological tests (p > .05, t-test). Diffuse cortical atrophy was detected for both ε4+ (p = .0001, permutation test) and ε4- patients (p = .0001, permutation test) relative to controls, and overall gray matter loss was about 15% in each patients group. Differences in gray matter loss between carriers and non-carriers mapped to the temporal cortex and right occipital pole (20% greater loss in carriers) and to the posterior cingulate, left orbitofrontal and dorsal fronto-parietal cortex (5-15% greater loss in non-carriers). APOE effect in AD was not significant (p > .74, ANOVA), but a significant APOE by region (temporal vs fronto-parietal cortex) interaction was detected (p = .002, ANOVA), in both early and late-onset patients (p <.05, ANOVA). We conclude that the ε4 allele modulates disease phenotype in AD, being associated with a pattern of differential temporal and fronto-parietal vulnerability.
| Original language | English |
|---|---|
| Pages (from-to) | 1090-1098 |
| Number of pages | 9 |
| Journal | NeuroImage |
| Volume | 45 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - May 1 2009 |
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Keywords
- Alzheimer's disease
- Apolipoprotein E
- Computational neuroanatomy
- Cortical atrophy
- MRI
ASJC Scopus subject areas
- Cognitive Neuroscience
- Neurology
Cite this
Mapping the effect of APOE ε4 on gray matter loss in Alzheimer's disease in vivo. / Pievani, M.; Rasser, P. E.; Galluzzi, S.; Benussi, L.; Ghidoni, R.; Sabattoli, F.; Bonetti, M.; Binetti, G.; Thompson, P. M.; Frisoni, G. B.
In: NeuroImage, Vol. 45, No. 4, 01.05.2009, p. 1090-1098.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mapping the effect of APOE ε4 on gray matter loss in Alzheimer's disease in vivo
AU - Pievani, M.
AU - Rasser, P. E.
AU - Galluzzi, S.
AU - Benussi, L.
AU - Ghidoni, R.
AU - Sabattoli, F.
AU - Bonetti, M.
AU - Binetti, G.
AU - Thompson, P. M.
AU - Frisoni, G. B.
PY - 2009/5/1
Y1 - 2009/5/1
N2 - Previous studies suggest that in Alzheimer's disease (AD) the Apolipoprotein E (APOE) ε4 allele is associated with greater vulnerability of medial temporal lobe structures. However, less is known about its effect on the whole cortical mantle. Here we aimed to identify APOE-related patterns of cortical atrophy in AD using an advanced computational anatomy technique. We studied 15 AD patients carriers (ε4+, age: 72 ± 10 SD years, MMSE: 20 ± 3 SD) and 14 non-carriers (ε4-, age: 69 ± 9, MMSE: 20 ± 5) of the ε4 allele and compared them to 29 age-and-sex matched controls (age: 70 ± 9, MMSE: 28 ± 1). Each subject underwent a clinical evaluation, a neuropsychological battery, and high-resolution MRI. UCLA's cortical pattern matching technique was used to identify regions of local cortical atrophy. ε4+ and ε4- patients showed similar performance on neuropsychological tests (p > .05, t-test). Diffuse cortical atrophy was detected for both ε4+ (p = .0001, permutation test) and ε4- patients (p = .0001, permutation test) relative to controls, and overall gray matter loss was about 15% in each patients group. Differences in gray matter loss between carriers and non-carriers mapped to the temporal cortex and right occipital pole (20% greater loss in carriers) and to the posterior cingulate, left orbitofrontal and dorsal fronto-parietal cortex (5-15% greater loss in non-carriers). APOE effect in AD was not significant (p > .74, ANOVA), but a significant APOE by region (temporal vs fronto-parietal cortex) interaction was detected (p = .002, ANOVA), in both early and late-onset patients (p <.05, ANOVA). We conclude that the ε4 allele modulates disease phenotype in AD, being associated with a pattern of differential temporal and fronto-parietal vulnerability.
AB - Previous studies suggest that in Alzheimer's disease (AD) the Apolipoprotein E (APOE) ε4 allele is associated with greater vulnerability of medial temporal lobe structures. However, less is known about its effect on the whole cortical mantle. Here we aimed to identify APOE-related patterns of cortical atrophy in AD using an advanced computational anatomy technique. We studied 15 AD patients carriers (ε4+, age: 72 ± 10 SD years, MMSE: 20 ± 3 SD) and 14 non-carriers (ε4-, age: 69 ± 9, MMSE: 20 ± 5) of the ε4 allele and compared them to 29 age-and-sex matched controls (age: 70 ± 9, MMSE: 28 ± 1). Each subject underwent a clinical evaluation, a neuropsychological battery, and high-resolution MRI. UCLA's cortical pattern matching technique was used to identify regions of local cortical atrophy. ε4+ and ε4- patients showed similar performance on neuropsychological tests (p > .05, t-test). Diffuse cortical atrophy was detected for both ε4+ (p = .0001, permutation test) and ε4- patients (p = .0001, permutation test) relative to controls, and overall gray matter loss was about 15% in each patients group. Differences in gray matter loss between carriers and non-carriers mapped to the temporal cortex and right occipital pole (20% greater loss in carriers) and to the posterior cingulate, left orbitofrontal and dorsal fronto-parietal cortex (5-15% greater loss in non-carriers). APOE effect in AD was not significant (p > .74, ANOVA), but a significant APOE by region (temporal vs fronto-parietal cortex) interaction was detected (p = .002, ANOVA), in both early and late-onset patients (p <.05, ANOVA). We conclude that the ε4 allele modulates disease phenotype in AD, being associated with a pattern of differential temporal and fronto-parietal vulnerability.
KW - Alzheimer's disease
KW - Apolipoprotein E
KW - Computational neuroanatomy
KW - Cortical atrophy
KW - MRI
UR - http://www.scopus.com/inward/record.url?scp=62049084844&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=62049084844&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2009.01.009
DO - 10.1016/j.neuroimage.2009.01.009
M3 - Article
VL - 45
SP - 1090
EP - 1098
JO - NeuroImage
JF - NeuroImage
SN - 1053-8119
IS - 4
ER -