Mapping the future of common diseases: Lessons from psoriasis

Emiliano Giardina, Cecilia Sinibaldi, Giuseppe Novelli

Research output: Contribution to journalArticle

Abstract

Psoriasis (OMIM* 177900) is a common, chronic, hyperproliferative inflammatory disorder of the skin affecting approximately 2% of Caucasians. Despite the prevalence of psoriasis in general population, significant differences in the incidence among Japanese, Eskimos, West Africans, north American blacks and American natives are well known. The cause for these variations are likely to be both genetic and environmental. Independent genomewide scans have suggested the involvement of a large number of chromosomal regions (loci), but so far only poor susceptibility genes have been suggested. We discuss genetic basis of the disease, results and interpretations of relevant studies, with particular regard to study design and future perspectives. Indeed to date, mapping genes which contribute to complex diseases is one of the major challenge in the post-genomic era. "But remember throughout that no cause is efficient without a predisposition of the body itself, otherwise, external factors which affect one would affect all." (Galen, 130-200 CE).

Original languageEnglish
Pages (from-to)1563-1573
Number of pages11
JournalFrontiers in Bioscience
Volume12
Issue number4
DOIs
Publication statusPublished - 2007

Keywords

  • Autoimmune-diseases
  • Complex diseases
  • HLA
  • Psoriasis
  • Psoriatic arthritis
  • Review
  • Susceptibility to complex disease

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

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