MARCH-I expression in cord blood CD34+KDR+ cells

Gioacchin Iannolo, Maria Rita Sciuto, Cristina La Rosa, Concetta Conticello

Research output: Contribution to journalArticle

Abstract

Hematopoietic stem cells transplantation has been successfully used in the treatment of patients with hematological malignances. A better knowledge of the mechanisms beyond their ability to completely repopulate the entire hematopoietic system would help in the treatment of hematological diseases. For this reason we focused our studies on a cell population that has been demonstrated to have some peculiar characteristics among the stem cells: CD34+KDR+ cells. These cells, an extremely rare population among the CD34 (0.1%-0.5%) cells, have been demonstrated from different groups to have the potential to give rise to the hematopoietic and endothelial lineage. By a subtraction library approach we found different sequences more expressed in CD34+KDR+ than their CD34+KDR- counterpart. In particular, we found an open reading frame correspondent to a newly characterized E3 ligase, MARCH-I. This gene is part of a recently described family involved in immune response modulation through the proteosomal mediated degradation. MARCH-I expression in stem cells could be important for their intrinsic immune properties.

Original languageEnglish
Pages (from-to)725-727
Number of pages3
JournalClinical Biochemistry
Volume44
Issue number8-9
DOIs
Publication statusPublished - Jun 2011

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Keywords

  • KDR
  • MARCH-I
  • Stem cell

ASJC Scopus subject areas

  • Clinical Biochemistry

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