Margin involvement and clinical pattern of basal cell carcinoma with mixed histology

R. Betti, G. Radaelli, C. Crosti, S. Ghiozzi, L. Moneghini, S. Menni

Research output: Contribution to journalArticle

Abstract

Background Mixed basal cell carcinoma (BCC) has not been sufficiently and specifically studied. Objective The aim of this study was to estimate in adults the prevalence of mixed cases observed among primary BCCs and to compare clinical and anatomical features of mixed vs. single BCCs, with focus on the incomplete excision. Patients and methods A total of 3636 histologically confirmed primary BCCs were examined. Data on gender, age, histological subtype, anatomical location and margin involvement were collected. Mixed type was defined as a combination of two or more single subtypes. Results Prevalence of single and mixed BCCs was 82.2% and 17.8% respectively. Prevalence of BCCs on the upper limbs was higher in mixed than single cases (8.8% vs. 4.0%; P <0.001) while prevalence on the back was lower (16.9% vs. 23.7%; P <0.001). Tumour was aggressive in 59.1% of mixed vs. 16.0% of single BCCs (P <0.001). Margin involvement was more prevalent in mixed than in single BCCs (16.7% vs. 9.6%; P <0.0001). At multivariate analysis being mixed vs. single BCC was associated with aggressiveness of tumour (OR = 8.5, 95% CI, 6.9-10.4), lateral margin involvement (OR = 1.98, 95% CI, 1.42-2.76) and subject being man (OR = 1.31, 95% CI, 1.10-1.60) but not with deep involvement of margin or anatomical location. Conclusion Among BCCs, the mixed type may be observed in adults with relatively high rate and may represent a complex and individual subset of BCCs with potential aggressive behaviour.

Original languageEnglish
Pages (from-to)483-487
Number of pages5
JournalJournal of the European Academy of Dermatology and Venereology
Volume26
Issue number4
DOIs
Publication statusPublished - Apr 2012

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Basal Cell Carcinoma
Histology
Upper Extremity
Neoplasms
Multivariate Analysis

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

Cite this

Margin involvement and clinical pattern of basal cell carcinoma with mixed histology. / Betti, R.; Radaelli, G.; Crosti, C.; Ghiozzi, S.; Moneghini, L.; Menni, S.

In: Journal of the European Academy of Dermatology and Venereology, Vol. 26, No. 4, 04.2012, p. 483-487.

Research output: Contribution to journalArticle

Betti, R. ; Radaelli, G. ; Crosti, C. ; Ghiozzi, S. ; Moneghini, L. ; Menni, S. / Margin involvement and clinical pattern of basal cell carcinoma with mixed histology. In: Journal of the European Academy of Dermatology and Venereology. 2012 ; Vol. 26, No. 4. pp. 483-487.
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title = "Margin involvement and clinical pattern of basal cell carcinoma with mixed histology",
abstract = "Background Mixed basal cell carcinoma (BCC) has not been sufficiently and specifically studied. Objective The aim of this study was to estimate in adults the prevalence of mixed cases observed among primary BCCs and to compare clinical and anatomical features of mixed vs. single BCCs, with focus on the incomplete excision. Patients and methods A total of 3636 histologically confirmed primary BCCs were examined. Data on gender, age, histological subtype, anatomical location and margin involvement were collected. Mixed type was defined as a combination of two or more single subtypes. Results Prevalence of single and mixed BCCs was 82.2{\%} and 17.8{\%} respectively. Prevalence of BCCs on the upper limbs was higher in mixed than single cases (8.8{\%} vs. 4.0{\%}; P <0.001) while prevalence on the back was lower (16.9{\%} vs. 23.7{\%}; P <0.001). Tumour was aggressive in 59.1{\%} of mixed vs. 16.0{\%} of single BCCs (P <0.001). Margin involvement was more prevalent in mixed than in single BCCs (16.7{\%} vs. 9.6{\%}; P <0.0001). At multivariate analysis being mixed vs. single BCC was associated with aggressiveness of tumour (OR = 8.5, 95{\%} CI, 6.9-10.4), lateral margin involvement (OR = 1.98, 95{\%} CI, 1.42-2.76) and subject being man (OR = 1.31, 95{\%} CI, 1.10-1.60) but not with deep involvement of margin or anatomical location. Conclusion Among BCCs, the mixed type may be observed in adults with relatively high rate and may represent a complex and individual subset of BCCs with potential aggressive behaviour.",
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T1 - Margin involvement and clinical pattern of basal cell carcinoma with mixed histology

AU - Betti, R.

AU - Radaelli, G.

AU - Crosti, C.

AU - Ghiozzi, S.

AU - Moneghini, L.

AU - Menni, S.

PY - 2012/4

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N2 - Background Mixed basal cell carcinoma (BCC) has not been sufficiently and specifically studied. Objective The aim of this study was to estimate in adults the prevalence of mixed cases observed among primary BCCs and to compare clinical and anatomical features of mixed vs. single BCCs, with focus on the incomplete excision. Patients and methods A total of 3636 histologically confirmed primary BCCs were examined. Data on gender, age, histological subtype, anatomical location and margin involvement were collected. Mixed type was defined as a combination of two or more single subtypes. Results Prevalence of single and mixed BCCs was 82.2% and 17.8% respectively. Prevalence of BCCs on the upper limbs was higher in mixed than single cases (8.8% vs. 4.0%; P <0.001) while prevalence on the back was lower (16.9% vs. 23.7%; P <0.001). Tumour was aggressive in 59.1% of mixed vs. 16.0% of single BCCs (P <0.001). Margin involvement was more prevalent in mixed than in single BCCs (16.7% vs. 9.6%; P <0.0001). At multivariate analysis being mixed vs. single BCC was associated with aggressiveness of tumour (OR = 8.5, 95% CI, 6.9-10.4), lateral margin involvement (OR = 1.98, 95% CI, 1.42-2.76) and subject being man (OR = 1.31, 95% CI, 1.10-1.60) but not with deep involvement of margin or anatomical location. Conclusion Among BCCs, the mixed type may be observed in adults with relatively high rate and may represent a complex and individual subset of BCCs with potential aggressive behaviour.

AB - Background Mixed basal cell carcinoma (BCC) has not been sufficiently and specifically studied. Objective The aim of this study was to estimate in adults the prevalence of mixed cases observed among primary BCCs and to compare clinical and anatomical features of mixed vs. single BCCs, with focus on the incomplete excision. Patients and methods A total of 3636 histologically confirmed primary BCCs were examined. Data on gender, age, histological subtype, anatomical location and margin involvement were collected. Mixed type was defined as a combination of two or more single subtypes. Results Prevalence of single and mixed BCCs was 82.2% and 17.8% respectively. Prevalence of BCCs on the upper limbs was higher in mixed than single cases (8.8% vs. 4.0%; P <0.001) while prevalence on the back was lower (16.9% vs. 23.7%; P <0.001). Tumour was aggressive in 59.1% of mixed vs. 16.0% of single BCCs (P <0.001). Margin involvement was more prevalent in mixed than in single BCCs (16.7% vs. 9.6%; P <0.0001). At multivariate analysis being mixed vs. single BCC was associated with aggressiveness of tumour (OR = 8.5, 95% CI, 6.9-10.4), lateral margin involvement (OR = 1.98, 95% CI, 1.42-2.76) and subject being man (OR = 1.31, 95% CI, 1.10-1.60) but not with deep involvement of margin or anatomical location. Conclusion Among BCCs, the mixed type may be observed in adults with relatively high rate and may represent a complex and individual subset of BCCs with potential aggressive behaviour.

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