Marine sponges and bacteria as challenging sources of enzyme inhibitors for pharmacological applications

Nadia Ruocco, Susan Costantini, Flora Palumbo, Maria Costantini

Research output: Contribution to journalReview article

Abstract

Enzymes play key roles in different cellular processes, for example, in signal transduction, cell differentiation and proliferation, metabolic processes, DNA damage repair, apoptosis, and response to stress. A deregulation of enzymes has been considered one of the first causes of several diseases, including cancers. In the last several years, enzyme inhibitors, being good candidates as drugs in the pathogenic processes, have received an increasing amount of attention for their potential application in pharmacology. The marine environment is considered a challenging source of enzyme inhibitors for pharmacological applications. In this review, we report on secondary metabolites with enzyme inhibitory activity, focusing our attention on marine sponges and bacteria as promising sources. In the case of sponges, we only reported the kinase inhibitors, because this class was the most representative isolated so far from these marine organisms.

Original languageEnglish
Article number173
JournalMarine Drugs
Volume15
Issue number6
DOIs
Publication statusPublished - Jun 1 2017

Keywords

  • Bacteria
  • Enzyme inhibitors
  • Sponges

ASJC Scopus subject areas

  • Drug Discovery

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