Marital status and gender affect stage, tumor grade, treatment type and cancer specific mortality in T1–2N0M0renal cell carcinoma

M Marchioni, T Martel, M Bandini, RS Pompe, Z Tian, A Kapoor, L Cindolo, Riccardo Autorino, A Briganti, SF Shariat, L Schips, PI Karakiewicz

Research output: Contribution to journalArticle

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Abstract

Purpose: To examine the effect of marital status and gender on stage at diagnosis, tumor grade, treatment type and cancer specific mortality (CSM) in patients with localized renal cell carcinoma (RCC). Methods: Within Surveillance, Epidemiology, and End Results registry (2001–2013), we identified 57,700 patients with T 1–2 N 0 M 0 RCC. Logistic regression and competing-risks regression models tested the effect of marital status and gender on stage, tumor grade, treatment type and cancer specific mortality (CSM). Results: Of all patients, 8.8, 10.6 and 14.8% were, respectively, widowed, separated/divorced and never married. The three categories accounted for 3.9, 9.0 and 14.9% of males (35,641) and for 16.7, 13.1 and 14.7% of females (22,059). Widowed (OR 1.13, p = 0.04), separated/divorced (OR 1.16, p = 0.02) and never married status (OR 1.38, p < 0.001) predisposed to higher rate of no surgical treatment. Widowed (HR 1.32, p < 0.001) and separated/divorced (HR 1.32, p < 0.001) status predisposed to higher CSM. Male gender predisposed to higher T-stage (OR 1.12, p < 0.001), higher tumor grade (OR 1.35, p < 0.001), no surgical treatment (OR 1.23, p < 0.001) and higher CSM (1.13, p = 0.01). Interaction tests between gender and marital status failed to reach independent predictor status in all analyses. Conclusions: Male patients are at higher risk of less favorable baseline characteristics. Additionally, male, widowed and separated/divorced patients exhibit worse cancer control outcomes after treatment for T 1–2 N 0 M 0 RCC. These observations indicate the need of more focused attention to those patients prior to, as well as after treatment for localized RCC. © 2017 Springer-Verlag GmbH Germany
Original languageEnglish
Pages (from-to)1899-1905
Number of pages7
JournalWorld Journal of Urology
Volume35
Issue number12
DOIs
Publication statusPublished - 2017

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Marital Status
Carcinoma
Widowhood
Divorce
Mortality
Renal Cell Carcinoma
Neoplasms
Therapeutics
Germany
Registries
Epidemiology
Logistic Models

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Marital status and gender affect stage, tumor grade, treatment type and cancer specific mortality in T1–2N0M0renal cell carcinoma. / Marchioni, M; Martel, T; Bandini, M; Pompe, RS; Tian, Z; Kapoor, A; Cindolo, L; Autorino, Riccardo; Briganti, A; Shariat, SF; Schips, L; Karakiewicz, PI.

In: World Journal of Urology, Vol. 35, No. 12, 2017, p. 1899-1905.

Research output: Contribution to journalArticle

Marchioni, M, Martel, T, Bandini, M, Pompe, RS, Tian, Z, Kapoor, A, Cindolo, L, Autorino, R, Briganti, A, Shariat, SF, Schips, L & Karakiewicz, PI 2017, 'Marital status and gender affect stage, tumor grade, treatment type and cancer specific mortality in T1–2N0M0renal cell carcinoma', World Journal of Urology, vol. 35, no. 12, pp. 1899-1905. https://doi.org/10.1007/s00345-017-2082-9
Marchioni, M ; Martel, T ; Bandini, M ; Pompe, RS ; Tian, Z ; Kapoor, A ; Cindolo, L ; Autorino, Riccardo ; Briganti, A ; Shariat, SF ; Schips, L ; Karakiewicz, PI. / Marital status and gender affect stage, tumor grade, treatment type and cancer specific mortality in T1–2N0M0renal cell carcinoma. In: World Journal of Urology. 2017 ; Vol. 35, No. 12. pp. 1899-1905.
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abstract = "Purpose: To examine the effect of marital status and gender on stage at diagnosis, tumor grade, treatment type and cancer specific mortality (CSM) in patients with localized renal cell carcinoma (RCC). Methods: Within Surveillance, Epidemiology, and End Results registry (2001–2013), we identified 57,700 patients with T 1–2 N 0 M 0 RCC. Logistic regression and competing-risks regression models tested the effect of marital status and gender on stage, tumor grade, treatment type and cancer specific mortality (CSM). Results: Of all patients, 8.8, 10.6 and 14.8{\%} were, respectively, widowed, separated/divorced and never married. The three categories accounted for 3.9, 9.0 and 14.9{\%} of males (35,641) and for 16.7, 13.1 and 14.7{\%} of females (22,059). Widowed (OR 1.13, p = 0.04), separated/divorced (OR 1.16, p = 0.02) and never married status (OR 1.38, p < 0.001) predisposed to higher rate of no surgical treatment. Widowed (HR 1.32, p < 0.001) and separated/divorced (HR 1.32, p < 0.001) status predisposed to higher CSM. Male gender predisposed to higher T-stage (OR 1.12, p < 0.001), higher tumor grade (OR 1.35, p < 0.001), no surgical treatment (OR 1.23, p < 0.001) and higher CSM (1.13, p = 0.01). Interaction tests between gender and marital status failed to reach independent predictor status in all analyses. Conclusions: Male patients are at higher risk of less favorable baseline characteristics. Additionally, male, widowed and separated/divorced patients exhibit worse cancer control outcomes after treatment for T 1–2 N 0 M 0 RCC. These observations indicate the need of more focused attention to those patients prior to, as well as after treatment for localized RCC. {\circledC} 2017 Springer-Verlag GmbH Germany",
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T1 - Marital status and gender affect stage, tumor grade, treatment type and cancer specific mortality in T1–2N0M0renal cell carcinoma

AU - Marchioni, M

AU - Martel, T

AU - Bandini, M

AU - Pompe, RS

AU - Tian, Z

AU - Kapoor, A

AU - Cindolo, L

AU - Autorino, Riccardo

AU - Briganti, A

AU - Shariat, SF

AU - Schips, L

AU - Karakiewicz, PI

PY - 2017

Y1 - 2017

N2 - Purpose: To examine the effect of marital status and gender on stage at diagnosis, tumor grade, treatment type and cancer specific mortality (CSM) in patients with localized renal cell carcinoma (RCC). Methods: Within Surveillance, Epidemiology, and End Results registry (2001–2013), we identified 57,700 patients with T 1–2 N 0 M 0 RCC. Logistic regression and competing-risks regression models tested the effect of marital status and gender on stage, tumor grade, treatment type and cancer specific mortality (CSM). Results: Of all patients, 8.8, 10.6 and 14.8% were, respectively, widowed, separated/divorced and never married. The three categories accounted for 3.9, 9.0 and 14.9% of males (35,641) and for 16.7, 13.1 and 14.7% of females (22,059). Widowed (OR 1.13, p = 0.04), separated/divorced (OR 1.16, p = 0.02) and never married status (OR 1.38, p < 0.001) predisposed to higher rate of no surgical treatment. Widowed (HR 1.32, p < 0.001) and separated/divorced (HR 1.32, p < 0.001) status predisposed to higher CSM. Male gender predisposed to higher T-stage (OR 1.12, p < 0.001), higher tumor grade (OR 1.35, p < 0.001), no surgical treatment (OR 1.23, p < 0.001) and higher CSM (1.13, p = 0.01). Interaction tests between gender and marital status failed to reach independent predictor status in all analyses. Conclusions: Male patients are at higher risk of less favorable baseline characteristics. Additionally, male, widowed and separated/divorced patients exhibit worse cancer control outcomes after treatment for T 1–2 N 0 M 0 RCC. These observations indicate the need of more focused attention to those patients prior to, as well as after treatment for localized RCC. © 2017 Springer-Verlag GmbH Germany

AB - Purpose: To examine the effect of marital status and gender on stage at diagnosis, tumor grade, treatment type and cancer specific mortality (CSM) in patients with localized renal cell carcinoma (RCC). Methods: Within Surveillance, Epidemiology, and End Results registry (2001–2013), we identified 57,700 patients with T 1–2 N 0 M 0 RCC. Logistic regression and competing-risks regression models tested the effect of marital status and gender on stage, tumor grade, treatment type and cancer specific mortality (CSM). Results: Of all patients, 8.8, 10.6 and 14.8% were, respectively, widowed, separated/divorced and never married. The three categories accounted for 3.9, 9.0 and 14.9% of males (35,641) and for 16.7, 13.1 and 14.7% of females (22,059). Widowed (OR 1.13, p = 0.04), separated/divorced (OR 1.16, p = 0.02) and never married status (OR 1.38, p < 0.001) predisposed to higher rate of no surgical treatment. Widowed (HR 1.32, p < 0.001) and separated/divorced (HR 1.32, p < 0.001) status predisposed to higher CSM. Male gender predisposed to higher T-stage (OR 1.12, p < 0.001), higher tumor grade (OR 1.35, p < 0.001), no surgical treatment (OR 1.23, p < 0.001) and higher CSM (1.13, p = 0.01). Interaction tests between gender and marital status failed to reach independent predictor status in all analyses. Conclusions: Male patients are at higher risk of less favorable baseline characteristics. Additionally, male, widowed and separated/divorced patients exhibit worse cancer control outcomes after treatment for T 1–2 N 0 M 0 RCC. These observations indicate the need of more focused attention to those patients prior to, as well as after treatment for localized RCC. © 2017 Springer-Verlag GmbH Germany

U2 - 10.1007/s00345-017-2082-9

DO - 10.1007/s00345-017-2082-9

M3 - Article

VL - 35

SP - 1899

EP - 1905

JO - World Journal of Urology

JF - World Journal of Urology

SN - 0724-4983

IS - 12

ER -