Marital status and gender affect stage, tumor grade, treatment type and cancer specific mortality in T1–2N0M0renal cell carcinoma

M Marchioni, T Martel, M Bandini, RS Pompe, Z Tian, A Kapoor, L Cindolo, Riccardo Autorino, A Briganti, SF Shariat, L Schips, PI Karakiewicz

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Abstract

Purpose: To examine the effect of marital status and gender on stage at diagnosis, tumor grade, treatment type and cancer specific mortality (CSM) in patients with localized renal cell carcinoma (RCC). Methods: Within Surveillance, Epidemiology, and End Results registry (2001–2013), we identified 57,700 patients with T 1–2 N 0 M 0 RCC. Logistic regression and competing-risks regression models tested the effect of marital status and gender on stage, tumor grade, treatment type and cancer specific mortality (CSM). Results: Of all patients, 8.8, 10.6 and 14.8% were, respectively, widowed, separated/divorced and never married. The three categories accounted for 3.9, 9.0 and 14.9% of males (35,641) and for 16.7, 13.1 and 14.7% of females (22,059). Widowed (OR 1.13, p = 0.04), separated/divorced (OR 1.16, p = 0.02) and never married status (OR 1.38, p < 0.001) predisposed to higher rate of no surgical treatment. Widowed (HR 1.32, p < 0.001) and separated/divorced (HR 1.32, p < 0.001) status predisposed to higher CSM. Male gender predisposed to higher T-stage (OR 1.12, p < 0.001), higher tumor grade (OR 1.35, p < 0.001), no surgical treatment (OR 1.23, p < 0.001) and higher CSM (1.13, p = 0.01). Interaction tests between gender and marital status failed to reach independent predictor status in all analyses. Conclusions: Male patients are at higher risk of less favorable baseline characteristics. Additionally, male, widowed and separated/divorced patients exhibit worse cancer control outcomes after treatment for T 1–2 N 0 M 0 RCC. These observations indicate the need of more focused attention to those patients prior to, as well as after treatment for localized RCC. © 2017 Springer-Verlag GmbH Germany
Original languageEnglish
Pages (from-to)1899-1905
Number of pages7
JournalWorld Journal of Urology
Volume35
Issue number12
DOIs
Publication statusPublished - 2017

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Marchioni, M., Martel, T., Bandini, M., Pompe, RS., Tian, Z., Kapoor, A., Cindolo, L., Autorino, R., Briganti, A., Shariat, SF., Schips, L., & Karakiewicz, PI. (2017). Marital status and gender affect stage, tumor grade, treatment type and cancer specific mortality in T1–2N0M0renal cell carcinoma. World Journal of Urology, 35(12), 1899-1905. https://doi.org/10.1007/s00345-017-2082-9