Marked decrease of plasma neuroactive steroids during alcohol withdrawal

E. Romeo, A. Brancati, A. De Lorenzo, P. Fucci, C. Furnari, E. Pompili, G. F. Sasso, G. Spalletta, A. Troisi, A. Pasini

Research output: Contribution to journalArticlepeer-review

Abstract

The neuroactive steroids allopregnanolone (ALLO) and allotetrahydrodeoxycorticosterone (THDOC) are the most potent endogenous positive modulators of γ-aminobutyric acid (GABA) on GABA(A) receptors, a receptor system presumably responsible for some behavioral responses to alcohol withdrawal. In a group of nine alcoholic subjects, the levels of plasma ALLO and THDOC were markedly lower than those of control subjects during the early withdrawal phase (day 4 and 5), when anxiety and depression scores were higher. In contrast ALLO and THDOC plasma levels did not differ from those of control subjects during the late withdrawal phase when anxiety and depression scores were low. These results suggest that the decrease of neuroactive steroid biosynthesis may contribute to the withdrawal symptoms.

Original languageEnglish
Pages (from-to)366-369
Number of pages4
JournalClinical Neuropharmacology
Volume19
Issue number4
Publication statusPublished - 1996

Keywords

  • Alcohol
  • Anxiety
  • Depression
  • Steroids
  • Withdrawal

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Clinical Neurology
  • Neuroscience(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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