TY - JOUR
T1 - Marked increase in etravirine and saquinavir plasma concentrations during atovaquone/proguanil prophylaxis
AU - Tommasi, Chiara
AU - Bellagamba, Rita
AU - Tempestilli, Massimo
AU - D'Avolio, Antonio
AU - Gallo, Anna L.
AU - Ivanovic, Jelena
AU - Nicastri, Emanuele
AU - Pucillo, Leopoldo P.
AU - Narciso, Pasquale
PY - 2011
Y1 - 2011
N2 - The case of a 32-year-old Caucasian female with multi-drug resistant HIV-1 subtype B infection treated with a salvage regimen including maraviroc, raltegravir, etravirine and unboosted saquinavir who started atovaquone/proguanil prophylaxis, is reported. The potential interactions between atovaquone/proguanil and these anti-retroviral drugs are investigated. Pharmacokinetic analyses documented a marked increase in etravirine and saquinavir plasma concentrations (+55% and +274%, respectively), but not in raltegravir and maraviroc plasma concentrations. The evidence that atovaquone/proguanil significantly interacts with etravirine and saquinavir, but not with raltegravir and maraviroc, suggests that the mechanism of interaction is related to cytochrome P450.
AB - The case of a 32-year-old Caucasian female with multi-drug resistant HIV-1 subtype B infection treated with a salvage regimen including maraviroc, raltegravir, etravirine and unboosted saquinavir who started atovaquone/proguanil prophylaxis, is reported. The potential interactions between atovaquone/proguanil and these anti-retroviral drugs are investigated. Pharmacokinetic analyses documented a marked increase in etravirine and saquinavir plasma concentrations (+55% and +274%, respectively), but not in raltegravir and maraviroc plasma concentrations. The evidence that atovaquone/proguanil significantly interacts with etravirine and saquinavir, but not with raltegravir and maraviroc, suggests that the mechanism of interaction is related to cytochrome P450.
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U2 - 10.1186/1475-2875-10-141
DO - 10.1186/1475-2875-10-141
M3 - Article
C2 - 21600016
AN - SCOPUS:79956189230
VL - 10
JO - Malaria Journal
JF - Malaria Journal
SN - 1475-2875
M1 - 141
ER -