Markers of activation of coagulation and fibrinolysis in patients with Cushing's syndrome

L. M. Fatti, B. Bottasso, C. Invitti, R. Coppola, Francesco Cavagnini, P. M. Mannucci

Research output: Contribution to journalArticle


Patients with active Cushing's syndrome have an increased thrombotic tendency. We chose to reassess the mechanism underlying the thrombophilic state associated with this clinical condition using sensitive markers of coagulation and fibrinolysis activation in 17 patients with active disease. The results were compared with those obtained in 12 Cushing's patients successfully treated by surgery and in 20 normal individuals. The general pattern of results in patients with active disease was the finding of increased levels of von Willebrand factor (VWF: Ag), a marker of enhanced metabolic function of endothelial cells (VWF:Ag 181±42 vs 110±43, p

Original languageEnglish
Pages (from-to)145-150
Number of pages6
JournalJournal of Endocrinological Investigation
Issue number3
Publication statusPublished - 2000



  • Cushing's syndrome
  • Fibrinolysis
  • Hypercoagulability
  • Thrombophilic state
  • Von Willebrand factor

ASJC Scopus subject areas

  • Endocrinology

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