Markers of human papillomavirus infection and their correlation with cervical dysplasia in human immunodeficiency virus-positive women

E. Riva, D. Serraino, A. Pierangeli, F. Bambacioni, S. Zaniratti, C. Minosse, M. Selleri, M. Bucci, C. Scagnolari, A. M. Degener, M. R. Capobianchi, Guido Antonelli, F. Dianzani

Research output: Contribution to journalArticle

Abstract

Human papillomavirus (HPV) genotypes and HPV DNA load were analysed in cervical smears from 76 human immunodeficiency virus (HIV)-positive and 54 HIV-negative women. The prevalence of genotypes was similar for all women, with the exception of HPV62, which was over-represented in HIV-positive samples. HIV-positive women showed a higher prevalence of multiple genotypes that correlated neither with CD4+ T-cell counts nor with cervical dysplasia. No significant differences were observed in terms of total or single-type HPV DNA load. The HPV DNA load in both HIV-positive and HIV-negative women was significantly higher in squamous intra-epithelial lesions than in negative Pap smears.

Original languageEnglish
Pages (from-to)94-97
Number of pages4
JournalClinical Microbiology and Infection
Volume13
Issue number1
DOIs
Publication statusPublished - Jan 2007

Keywords

  • Cervical dysplasia
  • DNA load
  • Genotypes
  • Human immunodeficiency virus
  • Human papillomavirus
  • Virological markers

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

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