Abstract
We wondered whether there was any association between the extent of increased angiogenesis and IgVH gene mutational status, expression of CD38 and ZAP-70 in early B-cell chronic lymphocytic leukemia (CLL) patients. Circulating levels of vascular endothelial growth factor (VEGF) correlated positively with ZAP-70-expression (P = 0.03), CD38- expression (P = 0.03) and mutational status of IgVH (P = 0.005). The same did not apply when correlations were sought with either bone marrow angiogenesis or serum levels of basic fibroblatic growth factor (FGF-2). Studies to determine how to integrate variables reflecting increased angiogenesis with other prognostic markers such as CD38, ZAP-70, IgVH status and cytogenetic abnormalities are needed to optimize risk stratification for individual patients.
Original language | English |
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Pages (from-to) | 1575-1578 |
Number of pages | 4 |
Journal | Leukemia Research |
Volume | 31 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 2007 |
Keywords
- Angiogenesis
- CD-38
- CLL
- IgVH mutational status
- ZAP-70
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology