Markers of increased angiogenesis and their correlation with biological parameters identifying high-risk patients in early B-cell chronic lymphocytic leukemia

Stefano Molica; Giovanna Cutrona; Gaetano Vitelli; Rosanna Mirabelli; Matteo Molica; Giovanna Digiesi; Domenico Ribatti; Manlio Ferrarini; Angelo Vacca

doi:10.1016/j.leukres.2007.03.009

Markers of increased angiogenesis and their correlation with biological parameters identifying high-risk patients in early B-cell chronic lymphocytic leukemia

Stefano Molica, Giovanna Cutrona, Gaetano Vitelli, Rosanna Mirabelli, Matteo Molica, Giovanna Digiesi, Domenico Ribatti, Manlio Ferrarini, Angelo Vacca

Research output: Contribution to journal › Article › peer-review

Abstract

We wondered whether there was any association between the extent of increased angiogenesis and IgV_H gene mutational status, expression of CD38 and ZAP-70 in early B-cell chronic lymphocytic leukemia (CLL) patients. Circulating levels of vascular endothelial growth factor (VEGF) correlated positively with ZAP-70-expression (P = 0.03), CD38- expression (P = 0.03) and mutational status of IgV_H (P = 0.005). The same did not apply when correlations were sought with either bone marrow angiogenesis or serum levels of basic fibroblatic growth factor (FGF-2). Studies to determine how to integrate variables reflecting increased angiogenesis with other prognostic markers such as CD38, ZAP-70, IgV_H status and cytogenetic abnormalities are needed to optimize risk stratification for individual patients.

Original language	English
Pages (from-to)	1575-1578
Number of pages	4
Journal	Leukemia Research
Volume	31
Issue number	11
DOIs	https://doi.org/10.1016/j.leukres.2007.03.009
Publication status	Published - Nov 2007

Keywords

Angiogenesis
CD-38
CLL
IgVH mutational status
ZAP-70

ASJC Scopus subject areas

Cancer Research
Hematology
Oncology

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Markers of increased angiogenesis and their correlation with biological parameters identifying high-risk patients in early B-cell chronic lymphocytic leukemia. / Molica, Stefano; Cutrona, Giovanna; Vitelli, Gaetano; Mirabelli, Rosanna; Molica, Matteo; Digiesi, Giovanna; Ribatti, Domenico; Ferrarini, Manlio; Vacca, Angelo.

In: Leukemia Research, Vol. 31, No. 11, 11.2007, p. 1575-1578.

Research output: Contribution to journal › Article › peer-review

Molica, S, Cutrona, G, Vitelli, G, Mirabelli, R, Molica, M, Digiesi, G, Ribatti, D, Ferrarini, M & Vacca, A 2007, 'Markers of increased angiogenesis and their correlation with biological parameters identifying high-risk patients in early B-cell chronic lymphocytic leukemia', Leukemia Research, vol. 31, no. 11, pp. 1575-1578. https://doi.org/10.1016/j.leukres.2007.03.009

Molica, Stefano ; Cutrona, Giovanna ; Vitelli, Gaetano ; Mirabelli, Rosanna ; Molica, Matteo ; Digiesi, Giovanna ; Ribatti, Domenico ; Ferrarini, Manlio ; Vacca, Angelo. / Markers of increased angiogenesis and their correlation with biological parameters identifying high-risk patients in early B-cell chronic lymphocytic leukemia. In: Leukemia Research. 2007 ; Vol. 31, No. 11. pp. 1575-1578.

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abstract = "We wondered whether there was any association between the extent of increased angiogenesis and IgVH gene mutational status, expression of CD38 and ZAP-70 in early B-cell chronic lymphocytic leukemia (CLL) patients. Circulating levels of vascular endothelial growth factor (VEGF) correlated positively with ZAP-70-expression (P = 0.03), CD38- expression (P = 0.03) and mutational status of IgVH (P = 0.005). The same did not apply when correlations were sought with either bone marrow angiogenesis or serum levels of basic fibroblatic growth factor (FGF-2). Studies to determine how to integrate variables reflecting increased angiogenesis with other prognostic markers such as CD38, ZAP-70, IgVH status and cytogenetic abnormalities are needed to optimize risk stratification for individual patients.",

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AU - Mirabelli, Rosanna

AU - Molica, Matteo

AU - Digiesi, Giovanna

AU - Ribatti, Domenico

AU - Ferrarini, Manlio

AU - Vacca, Angelo

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AB - We wondered whether there was any association between the extent of increased angiogenesis and IgVH gene mutational status, expression of CD38 and ZAP-70 in early B-cell chronic lymphocytic leukemia (CLL) patients. Circulating levels of vascular endothelial growth factor (VEGF) correlated positively with ZAP-70-expression (P = 0.03), CD38- expression (P = 0.03) and mutational status of IgVH (P = 0.005). The same did not apply when correlations were sought with either bone marrow angiogenesis or serum levels of basic fibroblatic growth factor (FGF-2). Studies to determine how to integrate variables reflecting increased angiogenesis with other prognostic markers such as CD38, ZAP-70, IgVH status and cytogenetic abnormalities are needed to optimize risk stratification for individual patients.

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Markers of increased angiogenesis and their correlation with biological parameters identifying high-risk patients in early B-cell chronic lymphocytic leukemia

Abstract

Keywords

ASJC Scopus subject areas

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