Markers of neuroinflammation influence measures of cortical thickness in bipolar depression

Sara Poletti, Giovanni Leone, Thomas A. Hoogenboezem, Davide Ghiglino, Benedetta Vai, Harm de Wit, Annemarie J.M. Wijkhuijs, Clara Locatelli, Cristina Colombo, Hemmo A. Drexhage, Francesco Benedetti

Research output: Contribution to journalArticlepeer-review


We tested if peripheral levels of cytokines and chemokines associate to grey matter volumes, cortical thickness and fMRI neural responses to a moral valence decision task in bipolar patients. ICAM1 and CCL4 negatively correlated with cortical thickness in Inferior Temporal Gyrus, and sCD25 in Parahippocampal Gyrus. TNF-α, Interleukine-8, and CCL2 correlated positively with cortical thickness in the Anterior Cingulate Cortex, and with lower BOLD responses to negative stimuli. Markers of immune activation are associated with measures of brain structural and functional integrity in bipolar depression.

Original languageEnglish
Pages (from-to)64-66
Number of pages3
JournalPsychiatry Research - Neuroimaging
Publication statusPublished - Mar 30 2019


  • Cytokines
  • Depression
  • Emotional processing

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health


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