Markers of neuroinflammation influence measures of cortical thickness in bipolar depression

Sara Poletti; Giovanni Leone; Thomas A. Hoogenboezem; Davide Ghiglino; Benedetta Vai; Harm de Wit; Annemarie J.M. Wijkhuijs; Clara Locatelli; Cristina Colombo; Hemmo A. Drexhage; Francesco Benedetti

doi:10.1016/j.pscychresns.2019.01.009

Markers of neuroinflammation influence measures of cortical thickness in bipolar depression

Sara Poletti, Giovanni Leone, Thomas A. Hoogenboezem, Davide Ghiglino, Benedetta Vai, Harm de Wit, Annemarie J.M. Wijkhuijs, Clara Locatelli, Cristina Colombo, Hemmo A. Drexhage, Francesco Benedetti

Research output: Contribution to journal › Article › peer-review

Abstract

We tested if peripheral levels of cytokines and chemokines associate to grey matter volumes, cortical thickness and fMRI neural responses to a moral valence decision task in bipolar patients. ICAM1 and CCL4 negatively correlated with cortical thickness in Inferior Temporal Gyrus, and sCD25 in Parahippocampal Gyrus. TNF-α, Interleukine-8, and CCL2 correlated positively with cortical thickness in the Anterior Cingulate Cortex, and with lower BOLD responses to negative stimuli. Markers of immune activation are associated with measures of brain structural and functional integrity in bipolar depression.

Original language	English
Pages (from-to)	64-66
Number of pages	3
Journal	Psychiatry Research - Neuroimaging
Volume	285
DOIs	https://doi.org/10.1016/j.pscychresns.2019.01.009
Publication status	Published - Mar 30 2019

Keywords

Cytokines
Depression
Emotional processing

ASJC Scopus subject areas

Neuroscience (miscellaneous)
Radiology Nuclear Medicine and imaging
Psychiatry and Mental health

Access to Document

10.1016/j.pscychresns.2019.01.009

Fingerprint Dive into the research topics of 'Markers of neuroinflammation influence measures of cortical thickness in bipolar depression'. Together they form a unique fingerprint.

Cite this

Markers of neuroinflammation influence measures of cortical thickness in bipolar depression. / Poletti, Sara; Leone, Giovanni; Hoogenboezem, Thomas A.; Ghiglino, Davide; Vai, Benedetta; de Wit, Harm; Wijkhuijs, Annemarie J.M.; Locatelli, Clara; Colombo, Cristina; Drexhage, Hemmo A.; Benedetti, Francesco.

In: Psychiatry Research - Neuroimaging, Vol. 285, 30.03.2019, p. 64-66.

Research output: Contribution to journal › Article › peer-review

Poletti, Sara ; Leone, Giovanni ; Hoogenboezem, Thomas A. ; Ghiglino, Davide ; Vai, Benedetta ; de Wit, Harm ; Wijkhuijs, Annemarie J.M. ; Locatelli, Clara ; Colombo, Cristina ; Drexhage, Hemmo A. ; Benedetti, Francesco. / Markers of neuroinflammation influence measures of cortical thickness in bipolar depression. In: Psychiatry Research - Neuroimaging. 2019 ; Vol. 285. pp. 64-66.

@article{4e0ae73039304f0ab4f99612d0e91e7e,

title = "Markers of neuroinflammation influence measures of cortical thickness in bipolar depression",

abstract = "We tested if peripheral levels of cytokines and chemokines associate to grey matter volumes, cortical thickness and fMRI neural responses to a moral valence decision task in bipolar patients. ICAM1 and CCL4 negatively correlated with cortical thickness in Inferior Temporal Gyrus, and sCD25 in Parahippocampal Gyrus. TNF-α, Interleukine-8, and CCL2 correlated positively with cortical thickness in the Anterior Cingulate Cortex, and with lower BOLD responses to negative stimuli. Markers of immune activation are associated with measures of brain structural and functional integrity in bipolar depression.",

keywords = "Cytokines, Depression, Emotional processing",

author = "Sara Poletti and Giovanni Leone and Hoogenboezem, {Thomas A.} and Davide Ghiglino and Benedetta Vai and {de Wit}, Harm and Wijkhuijs, {Annemarie J.M.} and Clara Locatelli and Cristina Colombo and Drexhage, {Hemmo A.} and Francesco Benedetti",

year = "2019",

month = mar,

day = "30",

doi = "10.1016/j.pscychresns.2019.01.009",

language = "English",

volume = "285",

pages = "64--66",

journal = "Psychiatry Research - Neuroimaging",

issn = "0925-4927",

publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Markers of neuroinflammation influence measures of cortical thickness in bipolar depression

AU - Poletti, Sara

AU - Leone, Giovanni

AU - Hoogenboezem, Thomas A.

AU - Ghiglino, Davide

AU - Vai, Benedetta

AU - de Wit, Harm

AU - Wijkhuijs, Annemarie J.M.

AU - Locatelli, Clara

AU - Colombo, Cristina

AU - Drexhage, Hemmo A.

AU - Benedetti, Francesco

PY - 2019/3/30

Y1 - 2019/3/30

N2 - We tested if peripheral levels of cytokines and chemokines associate to grey matter volumes, cortical thickness and fMRI neural responses to a moral valence decision task in bipolar patients. ICAM1 and CCL4 negatively correlated with cortical thickness in Inferior Temporal Gyrus, and sCD25 in Parahippocampal Gyrus. TNF-α, Interleukine-8, and CCL2 correlated positively with cortical thickness in the Anterior Cingulate Cortex, and with lower BOLD responses to negative stimuli. Markers of immune activation are associated with measures of brain structural and functional integrity in bipolar depression.

AB - We tested if peripheral levels of cytokines and chemokines associate to grey matter volumes, cortical thickness and fMRI neural responses to a moral valence decision task in bipolar patients. ICAM1 and CCL4 negatively correlated with cortical thickness in Inferior Temporal Gyrus, and sCD25 in Parahippocampal Gyrus. TNF-α, Interleukine-8, and CCL2 correlated positively with cortical thickness in the Anterior Cingulate Cortex, and with lower BOLD responses to negative stimuli. Markers of immune activation are associated with measures of brain structural and functional integrity in bipolar depression.

KW - Cytokines

KW - Depression

KW - Emotional processing

UR - http://www.scopus.com/inward/record.url?scp=85061633707&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061633707&partnerID=8YFLogxK

U2 - 10.1016/j.pscychresns.2019.01.009

DO - 10.1016/j.pscychresns.2019.01.009

M3 - Article

C2 - 30785023

AN - SCOPUS:85061633707

VL - 285

SP - 64

EP - 66

JO - Psychiatry Research - Neuroimaging

JF - Psychiatry Research - Neuroimaging

SN - 0925-4927

ER -

Markers of neuroinflammation influence measures of cortical thickness in bipolar depression

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Cite this