TY - JOUR
T1 - Markers of neuroinflammation influence measures of cortical thickness in bipolar depression
AU - Poletti, Sara
AU - Leone, Giovanni
AU - Hoogenboezem, Thomas A.
AU - Ghiglino, Davide
AU - Vai, Benedetta
AU - de Wit, Harm
AU - Wijkhuijs, Annemarie J.M.
AU - Locatelli, Clara
AU - Colombo, Cristina
AU - Drexhage, Hemmo A.
AU - Benedetti, Francesco
PY - 2019/3/30
Y1 - 2019/3/30
N2 - We tested if peripheral levels of cytokines and chemokines associate to grey matter volumes, cortical thickness and fMRI neural responses to a moral valence decision task in bipolar patients. ICAM1 and CCL4 negatively correlated with cortical thickness in Inferior Temporal Gyrus, and sCD25 in Parahippocampal Gyrus. TNF-α, Interleukine-8, and CCL2 correlated positively with cortical thickness in the Anterior Cingulate Cortex, and with lower BOLD responses to negative stimuli. Markers of immune activation are associated with measures of brain structural and functional integrity in bipolar depression.
AB - We tested if peripheral levels of cytokines and chemokines associate to grey matter volumes, cortical thickness and fMRI neural responses to a moral valence decision task in bipolar patients. ICAM1 and CCL4 negatively correlated with cortical thickness in Inferior Temporal Gyrus, and sCD25 in Parahippocampal Gyrus. TNF-α, Interleukine-8, and CCL2 correlated positively with cortical thickness in the Anterior Cingulate Cortex, and with lower BOLD responses to negative stimuli. Markers of immune activation are associated with measures of brain structural and functional integrity in bipolar depression.
KW - Cytokines
KW - Depression
KW - Emotional processing
UR - http://www.scopus.com/inward/record.url?scp=85061633707&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061633707&partnerID=8YFLogxK
U2 - 10.1016/j.pscychresns.2019.01.009
DO - 10.1016/j.pscychresns.2019.01.009
M3 - Article
C2 - 30785023
AN - SCOPUS:85061633707
VL - 285
SP - 64
EP - 66
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
SN - 0925-4927
ER -