Abstract
In 107 asymptomatic and untreated patients with inherited syndromes associated with thrombophilia (antithrombin III, protein C and protein S deficiencies), we compared in parallel two plasma peptides which reflect activation of the common coagulation pathway: the prothrombin fragment 1 + 2 (F1+2) and fibrinopeptide A (FPA). Both F1+2 and FPA were measured with simple, commercially available ELISA methods. High levels of F1+2 or FPA were found in about one fourth of the patients as a whole. When patients were divided according to the type of inherited thrombophilic syndrome, it appeared that F1+2 was more frequently elevated in protein C and protein S deficiencies than in antithrombin deficiency; and that, in general, it was no more frequently elevated than FPA. Although our data confirm the existence of a procoagulant imbalance in inherited thrombophilic syndromes due to defects of natural anticoagulant proteins, they do not confirm that such imbalance can be more frequently diagnosed by measuring F1+2 levels, particularly in patients with antithrombin deficiency.
| Original language | English |
|---|---|
| Pages (from-to) | 200-202 |
| Number of pages | 3 |
| Journal | Thrombosis and Haemostasis |
| Volume | 67 |
| Issue number | 2 |
| Publication status | Published - 1992 |
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ASJC Scopus subject areas
- Hematology
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Markers of procoagulant imbalance in patients with inherited thrombophilic syndromes. / Mannucci, P. M.; Tripodi, A.; Bottasso, B.; Baudo, F.; Finazzi, G.; De Stefano, V.; Palareti, G.; Manotti, C.; Mazzucconi, M. G.; Castaman, G.
In: Thrombosis and Haemostasis, Vol. 67, No. 2, 1992, p. 200-202.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Markers of procoagulant imbalance in patients with inherited thrombophilic syndromes
AU - Mannucci, P. M.
AU - Tripodi, A.
AU - Bottasso, B.
AU - Baudo, F.
AU - Finazzi, G.
AU - De Stefano, V.
AU - Palareti, G.
AU - Manotti, C.
AU - Mazzucconi, M. G.
AU - Castaman, G.
PY - 1992
Y1 - 1992
N2 - In 107 asymptomatic and untreated patients with inherited syndromes associated with thrombophilia (antithrombin III, protein C and protein S deficiencies), we compared in parallel two plasma peptides which reflect activation of the common coagulation pathway: the prothrombin fragment 1 + 2 (F1+2) and fibrinopeptide A (FPA). Both F1+2 and FPA were measured with simple, commercially available ELISA methods. High levels of F1+2 or FPA were found in about one fourth of the patients as a whole. When patients were divided according to the type of inherited thrombophilic syndrome, it appeared that F1+2 was more frequently elevated in protein C and protein S deficiencies than in antithrombin deficiency; and that, in general, it was no more frequently elevated than FPA. Although our data confirm the existence of a procoagulant imbalance in inherited thrombophilic syndromes due to defects of natural anticoagulant proteins, they do not confirm that such imbalance can be more frequently diagnosed by measuring F1+2 levels, particularly in patients with antithrombin deficiency.
AB - In 107 asymptomatic and untreated patients with inherited syndromes associated with thrombophilia (antithrombin III, protein C and protein S deficiencies), we compared in parallel two plasma peptides which reflect activation of the common coagulation pathway: the prothrombin fragment 1 + 2 (F1+2) and fibrinopeptide A (FPA). Both F1+2 and FPA were measured with simple, commercially available ELISA methods. High levels of F1+2 or FPA were found in about one fourth of the patients as a whole. When patients were divided according to the type of inherited thrombophilic syndrome, it appeared that F1+2 was more frequently elevated in protein C and protein S deficiencies than in antithrombin deficiency; and that, in general, it was no more frequently elevated than FPA. Although our data confirm the existence of a procoagulant imbalance in inherited thrombophilic syndromes due to defects of natural anticoagulant proteins, they do not confirm that such imbalance can be more frequently diagnosed by measuring F1+2 levels, particularly in patients with antithrombin deficiency.
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UR - http://www.scopus.com/inward/citedby.url?scp=0026574541&partnerID=8YFLogxK
M3 - Article
C2 - 1535736
AN - SCOPUS:0026574541
VL - 67
SP - 200
EP - 202
JO - Thrombosis and Haemostasis
JF - Thrombosis and Haemostasis
SN - 0340-6245
IS - 2
ER -