Markers of procoagulant imbalance in patients with inherited thrombophilic syndromes

P. M. Mannucci, A. Tripodi, B. Bottasso, F. Baudo, G. Finazzi, V. De Stefano, G. Palareti, C. Manotti, M. G. Mazzucconi, G. Castaman

Research output: Contribution to journalArticlepeer-review

Abstract

In 107 asymptomatic and untreated patients with inherited syndromes associated with thrombophilia (antithrombin III, protein C and protein S deficiencies), we compared in parallel two plasma peptides which reflect activation of the common coagulation pathway: the prothrombin fragment 1 + 2 (F1+2) and fibrinopeptide A (FPA). Both F1+2 and FPA were measured with simple, commercially available ELISA methods. High levels of F1+2 or FPA were found in about one fourth of the patients as a whole. When patients were divided according to the type of inherited thrombophilic syndrome, it appeared that F1+2 was more frequently elevated in protein C and protein S deficiencies than in antithrombin deficiency; and that, in general, it was no more frequently elevated than FPA. Although our data confirm the existence of a procoagulant imbalance in inherited thrombophilic syndromes due to defects of natural anticoagulant proteins, they do not confirm that such imbalance can be more frequently diagnosed by measuring F1+2 levels, particularly in patients with antithrombin deficiency.

Original languageEnglish
Pages (from-to)200-202
Number of pages3
JournalThrombosis and Haemostasis
Volume67
Issue number2
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Hematology

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