Markers of tubular damage in pre-eclampsia

D. M. Paternoster, A. Stella, G. L. Babbo, R. Pignataro, M. Mussap, M. Plebani

Research output: Contribution to journalArticlepeer-review


Background. The aim of this study is to investigate the tubular damage markers in preeclampsia and in pregnancy induced hypertension (PIH). Methods. This transversal study involved 111 women admitted to the Department of Obstetric and Gynaecology, University Hospital, Padua (Italy) and was conducted from the 24th week until delivery: 23 had normal pregnancies, 54 manifest pre-eclampsia, and 34 manifested pregnancy-induced hypertension (PIH) without superimposed pre-eclampsia. The following laboratory tests were performed: U-αl microglobulin, U-NAG, uric acid and microalbuminuria. The four groups were compared using the Mann-Whitney test and the Kruskall-Wallis test for multiple comparisons. A value of pψ0.05 was considered as statistically significant. Results. As for the markers of tubular damage, the values for urinary NAG were significantly lower in the control group (0.97 U/mmol Creat) than in the pre-eclampsia group (2.89 U/mmol Creat), and the PIH group (2.12 U/mmol Creat) (p

Original languageEnglish
Pages (from-to)373-377
Number of pages5
JournalMinerva Ginecologica
Issue number10
Publication statusPublished - 1999


  • Alphalmicro-globuline, urine
  • Hypertension acetylglucosaminidase, urine
  • Kidney tubules
  • Pre-eclampsia
  • Pregnancy complications, cardiovascular

ASJC Scopus subject areas

  • Obstetrics and Gynaecology


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