Masked Philadelphia chromosome caused by translocation (9;11;22)

Mario Sessarego; Francesco Pasquali; Giovanna Libera Bianchi Scarrà; Franco Ajmar

doi:10.1016/0165-4608(83)90074-2

Masked Philadelphia chromosome caused by translocation (9;11;22)

Mario Sessarego, Francesco Pasquali, Giovanna Libera Bianchi Scarrà, Franco Ajmar

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

In a patient with chronic myelocytic leukemia (CML), chromosome analysis revealed a translocation involving chromosomes No. 9, 11, and 22, with three break points, thus giving origin to a so-called "masked" Philadelphia chromosome (Ph¹). A review of similar cases reported in the literature indicates that a masked Ph¹ is very rare, that the chromosomes involved vary from case to case, and that in most cases the pattern of the rearrangement is quite different from that of two- and three-chromosome variant Ph¹ translocations.

Original language	English
Pages (from-to)	319-323
Number of pages	5
Journal	Cancer Genetics and Cytogenetics
Volume	8
Issue number	4
DOIs	https://doi.org/10.1016/0165-4608(83)90074-2
Publication status	Published - 1983

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

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abstract = "In a patient with chronic myelocytic leukemia (CML), chromosome analysis revealed a translocation involving chromosomes No. 9, 11, and 22, with three break points, thus giving origin to a so-called {"}masked{"} Philadelphia chromosome (Ph1). A review of similar cases reported in the literature indicates that a masked Ph1 is very rare, that the chromosomes involved vary from case to case, and that in most cases the pattern of the rearrangement is quite different from that of two- and three-chromosome variant Ph1 translocations.",

author = "Mario Sessarego and Francesco Pasquali and Scarr{\`a}, {Giovanna Libera Bianchi} and Franco Ajmar",

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AU - Pasquali, Francesco

AU - Scarrà, Giovanna Libera Bianchi

AU - Ajmar, Franco

PY - 1983

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AB - In a patient with chronic myelocytic leukemia (CML), chromosome analysis revealed a translocation involving chromosomes No. 9, 11, and 22, with three break points, thus giving origin to a so-called "masked" Philadelphia chromosome (Ph1). A review of similar cases reported in the literature indicates that a masked Ph1 is very rare, that the chromosomes involved vary from case to case, and that in most cases the pattern of the rearrangement is quite different from that of two- and three-chromosome variant Ph1 translocations.

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