Masked Philadelphia chromosome due to atypical BCR/ABL localization on the 9q34 band and duplication of the der(9) in a case of chronic myelogenous leukemia

Giuseppina Fugazza; Anna Garuti; Stefania Marchelli; Maurizio Miglino; Roberto Bruzzone; Anna Maria Gatti; Sandra Castello; Mario Sessarego

doi:10.1016/j.cancergencyto.2005.05.010

Masked Philadelphia chromosome due to atypical BCR/ABL localization on the 9q34 band and duplication of the der(9) in a case of chronic myelogenous leukemia

Giuseppina Fugazza, Anna Garuti, Stefania Marchelli, Maurizio Miglino, Roberto Bruzzone, Anna Maria Gatti, Sandra Castello, Mario Sessarego

A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)

Research output: Contribution to journal › Article › peer-review

Abstract

The cytogenetic studies and molecular evaluation of a Philadelphia chromosome negative chronic myelogenous leukemia patient with trisomy 21 (100% metaphases) and trisomy 9 (50% metaphases) at diagnosis are described. Fluorescence in situ hybridization revealed an atypical location of the BCR/ABL fusion signal on 9q, which was duplicated in cells with trisomy 9 simulating a double Ph. The patient was successfully treated with Glivec (also known as Gleevec; Novartis, Basel, Switzerland) and achieved complete hematological and cytogenetic response as well as a reduction of BCR/ABL transcripts detected by real-time quantitative PCR.

Original language	English
Pages (from-to)	173-175
Number of pages	3
Journal	Cancer Genetics and Cytogenetics
Volume	163
Issue number	2
DOIs	https://doi.org/10.1016/j.cancergencyto.2005.05.010
Publication status	Published - Dec 2005

ASJC Scopus subject areas

Cancer Research
Genetics
Molecular Biology

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10.1016/j.cancergencyto.2005.05.010

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Fugazza, G., Garuti, A., Marchelli, S., Miglino, M., Bruzzone, R., Gatti, A. M., Castello, S., & Sessarego, M. (2005). Masked Philadelphia chromosome due to atypical BCR/ABL localization on the 9q34 band and duplication of the der(9) in a case of chronic myelogenous leukemia. Cancer Genetics and Cytogenetics, 163(2), 173-175. https://doi.org/10.1016/j.cancergencyto.2005.05.010

Fugazza, G, Garuti, A, Marchelli, S, Miglino, M, Bruzzone, R, Gatti, AM, Castello, S & Sessarego, M 2005, 'Masked Philadelphia chromosome due to atypical BCR/ABL localization on the 9q34 band and duplication of the der(9) in a case of chronic myelogenous leukemia', Cancer Genetics and Cytogenetics, vol. 163, no. 2, pp. 173-175. https://doi.org/10.1016/j.cancergencyto.2005.05.010

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abstract = "The cytogenetic studies and molecular evaluation of a Philadelphia chromosome negative chronic myelogenous leukemia patient with trisomy 21 (100% metaphases) and trisomy 9 (50% metaphases) at diagnosis are described. Fluorescence in situ hybridization revealed an atypical location of the BCR/ABL fusion signal on 9q, which was duplicated in cells with trisomy 9 simulating a double Ph. The patient was successfully treated with Glivec (also known as Gleevec; Novartis, Basel, Switzerland) and achieved complete hematological and cytogenetic response as well as a reduction of BCR/ABL transcripts detected by real-time quantitative PCR.",

author = "Giuseppina Fugazza and Anna Garuti and Stefania Marchelli and Maurizio Miglino and Roberto Bruzzone and Gatti, {Anna Maria} and Sandra Castello and Mario Sessarego",

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doi = "10.1016/j.cancergencyto.2005.05.010",

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AU - Marchelli, Stefania

AU - Miglino, Maurizio

AU - Bruzzone, Roberto

AU - Gatti, Anna Maria

AU - Castello, Sandra

AU - Sessarego, Mario

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AB - The cytogenetic studies and molecular evaluation of a Philadelphia chromosome negative chronic myelogenous leukemia patient with trisomy 21 (100% metaphases) and trisomy 9 (50% metaphases) at diagnosis are described. Fluorescence in situ hybridization revealed an atypical location of the BCR/ABL fusion signal on 9q, which was duplicated in cells with trisomy 9 simulating a double Ph. The patient was successfully treated with Glivec (also known as Gleevec; Novartis, Basel, Switzerland) and achieved complete hematological and cytogenetic response as well as a reduction of BCR/ABL transcripts detected by real-time quantitative PCR.

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Masked Philadelphia chromosome due to atypical BCR/ABL localization on the 9q34 band and duplication of the der(9) in a case of chronic myelogenous leukemia

Abstract

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