Abstract
The cytogenetic studies and molecular evaluation of a Philadelphia chromosome negative chronic myelogenous leukemia patient with trisomy 21 (100% metaphases) and trisomy 9 (50% metaphases) at diagnosis are described. Fluorescence in situ hybridization revealed an atypical location of the BCR/ABL fusion signal on 9q, which was duplicated in cells with trisomy 9 simulating a double Ph. The patient was successfully treated with Glivec (also known as Gleevec; Novartis, Basel, Switzerland) and achieved complete hematological and cytogenetic response as well as a reduction of BCR/ABL transcripts detected by real-time quantitative PCR.
| Original language | English |
|---|---|
| Pages (from-to) | 173-175 |
| Number of pages | 3 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 163 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Dec 2005 |
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ASJC Scopus subject areas
- Cancer Research
- Genetics
- Molecular Biology
Cite this
Masked Philadelphia chromosome due to atypical BCR/ABL localization on the 9q34 band and duplication of the der(9) in a case of chronic myelogenous leukemia. / Fugazza, Giuseppina; Garuti, Anna; Marchelli, Stefania; Miglino, Maurizio; Bruzzone, Roberto; Gatti, Anna Maria; Castello, Sandra; Sessarego, Mario.
In: Cancer Genetics and Cytogenetics, Vol. 163, No. 2, 12.2005, p. 173-175.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Masked Philadelphia chromosome due to atypical BCR/ABL localization on the 9q34 band and duplication of the der(9) in a case of chronic myelogenous leukemia
AU - Fugazza, Giuseppina
AU - Garuti, Anna
AU - Marchelli, Stefania
AU - Miglino, Maurizio
AU - Bruzzone, Roberto
AU - Gatti, Anna Maria
AU - Castello, Sandra
AU - Sessarego, Mario
PY - 2005/12
Y1 - 2005/12
N2 - The cytogenetic studies and molecular evaluation of a Philadelphia chromosome negative chronic myelogenous leukemia patient with trisomy 21 (100% metaphases) and trisomy 9 (50% metaphases) at diagnosis are described. Fluorescence in situ hybridization revealed an atypical location of the BCR/ABL fusion signal on 9q, which was duplicated in cells with trisomy 9 simulating a double Ph. The patient was successfully treated with Glivec (also known as Gleevec; Novartis, Basel, Switzerland) and achieved complete hematological and cytogenetic response as well as a reduction of BCR/ABL transcripts detected by real-time quantitative PCR.
AB - The cytogenetic studies and molecular evaluation of a Philadelphia chromosome negative chronic myelogenous leukemia patient with trisomy 21 (100% metaphases) and trisomy 9 (50% metaphases) at diagnosis are described. Fluorescence in situ hybridization revealed an atypical location of the BCR/ABL fusion signal on 9q, which was duplicated in cells with trisomy 9 simulating a double Ph. The patient was successfully treated with Glivec (also known as Gleevec; Novartis, Basel, Switzerland) and achieved complete hematological and cytogenetic response as well as a reduction of BCR/ABL transcripts detected by real-time quantitative PCR.
UR - http://www.scopus.com/inward/record.url?scp=28744446144&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28744446144&partnerID=8YFLogxK
U2 - 10.1016/j.cancergencyto.2005.05.010
DO - 10.1016/j.cancergencyto.2005.05.010
M3 - Article
C2 - 16337863
AN - SCOPUS:28744446144
VL - 163
SP - 173
EP - 175
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -