TY - JOUR
T1 - Masked polycythemia vera diagnosed according to WHO and BCSH classification
AU - Barbui, Tiziano
AU - Thiele, Jürgen
AU - Carobbio, Alessandra
AU - Gisslinger, Heinz
AU - Finazzi, Guido
AU - Rumi, Elisa
AU - Luigia Randi, Maria
AU - Vannucchi, Alessandro M.
AU - Gisslinger, Bettina
AU - Müllauer, Leonhard
AU - Ruggeri, Marco
AU - Rambaldi, Alessandro
AU - Tefferi, Ayalew
PY - 2014
Y1 - 2014
N2 - Polycythemia vera (PV) is currently diagnosed by the World Health Organization (WHO) criteria regarding hemoglobin (HB) levels and JAK2V617F and related mutations or by the British Committee for Standards in Haematology (BCSH) guidelines predominantly based on hematocrit (HCT) values (>52% in men and >48% in women) in JAK2 mutated patients. We examined clinical features at diagnosis and outcome in 397 mutated PV patients showing a bone marrow (BM) morphology conforming with the WHO descriptions but including also cases with a HB level 65 years and white blood cell count >15 × 109/L. Without these risk factors mPV patients had the same survival as overt PV suggesting that a fraction of patients with HB lower than that required for WHO diagnosis should still be considered as overt PV. This study has established the existence of mPV by two different classification systems based on either HB or HCT threshold values.
AB - Polycythemia vera (PV) is currently diagnosed by the World Health Organization (WHO) criteria regarding hemoglobin (HB) levels and JAK2V617F and related mutations or by the British Committee for Standards in Haematology (BCSH) guidelines predominantly based on hematocrit (HCT) values (>52% in men and >48% in women) in JAK2 mutated patients. We examined clinical features at diagnosis and outcome in 397 mutated PV patients showing a bone marrow (BM) morphology conforming with the WHO descriptions but including also cases with a HB level 65 years and white blood cell count >15 × 109/L. Without these risk factors mPV patients had the same survival as overt PV suggesting that a fraction of patients with HB lower than that required for WHO diagnosis should still be considered as overt PV. This study has established the existence of mPV by two different classification systems based on either HB or HCT threshold values.
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U2 - 10.1002/ajh.23617
DO - 10.1002/ajh.23617
M3 - Article
C2 - 24166817
AN - SCOPUS:84893964717
VL - 89
SP - 199
EP - 202
JO - American Journal of Hematology
JF - American Journal of Hematology
SN - 0361-8609
IS - 2
ER -