Masked polycythemia vera diagnosed according to WHO and BCSH classification

Tiziano Barbui, Jürgen Thiele, Alessandra Carobbio, Heinz Gisslinger, Guido Finazzi, Elisa Rumi, Maria Luigia Randi, Alessandro M. Vannucchi, Bettina Gisslinger, Leonhard Müllauer, Marco Ruggeri, Alessandro Rambaldi, Ayalew Tefferi

Research output: Contribution to journalArticlepeer-review


Polycythemia vera (PV) is currently diagnosed by the World Health Organization (WHO) criteria regarding hemoglobin (HB) levels and JAK2V617F and related mutations or by the British Committee for Standards in Haematology (BCSH) guidelines predominantly based on hematocrit (HCT) values (>52% in men and >48% in women) in JAK2 mutated patients. We examined clinical features at diagnosis and outcome in 397 mutated PV patients showing a bone marrow (BM) morphology conforming with the WHO descriptions but including also cases with a HB level 65 years and white blood cell count >15 × 109/L. Without these risk factors mPV patients had the same survival as overt PV suggesting that a fraction of patients with HB lower than that required for WHO diagnosis should still be considered as overt PV. This study has established the existence of mPV by two different classification systems based on either HB or HCT threshold values.

Original languageEnglish
Pages (from-to)199-202
Number of pages4
JournalAmerican Journal of Hematology
Issue number2
Publication statusPublished - 2014

ASJC Scopus subject areas

  • Hematology


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