MASPIN's prognostic role in patients with advanced head and neck carcinoma treated with primary chemotherapy (carboplatin plus vinorelbine) and radiotherapy: Preliminary evidence

Gino Marioni, Haralabos Koussis, Elena Gaio, Luciano Giacomelli, Andy Bertolin, Emiliano D'Alessandro, Annamaria Scola, Giancarlo Ottaviano, Cosimo De Filippis, Antonio Jirillo, Alberto Staffieri, Stella Blandamura

Research output: Contribution to journalArticle

Abstract

Conclusions: Our very preliminary results support the hypothesis that MASPIN expression in primary head and neck squamous cell carcinoma (HNSCC) may be a valuable parameter for predicting patients' responses to a treatment based on carboplatin plus vinorelbine combined with radiotherapy. Objectives: The roles of induction chemotherapy and combined chemoradiotherapy in the treatment of locally advanced unresectable HNSCCs have evolved rapidly. MASPIN has a unique tumour-suppressing activity. Experimental evidence has shown that MASPIN suppresses tumour growth, angiogenesis, invasion and metastasis. We investigated the potential prognostic roles of MASPIN and p53 in a series of HNSCCs treated with carboplatin plus vinorelbine combined with radiotherapy. Patients and methods: Nineteen consecutive stage III or IV HNSCC patients were recruited. The treatment plan consisted of the administration of carboplatin on day 1 and vinorelbine on days 1 and 8. Four weeks later, carboplatin was administered concomitantly with radiation therapy. Expression of MASPIN and p53 was determined immunohistochemically in HNSCC diagnostic biopsies. Results: A significant inverse relation was found between MASPIN expression and cN staging (p=0.003). From a prognostic viewpoint, MASPIN expression was directly correlated with chemoradiotherapy response (p=0.041). Moreover, the log-rank test showed a significant relationship between higher MASPIN expression and longer disease-free survival (p=0.03), overall survival (p=0.006) and disease-specific survival (p=0.007).

Original languageEnglish
Pages (from-to)786-792
Number of pages7
JournalActa Oto-Laryngologica
Volume129
Issue number7
DOIs
Publication statusPublished - 2009

Keywords

  • Carboplatin
  • Head and neck carcinoma
  • MASPIN
  • Prognosis
  • Radiotherapy
  • Vinorelbine

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Marioni, G., Koussis, H., Gaio, E., Giacomelli, L., Bertolin, A., D'Alessandro, E., Scola, A., Ottaviano, G., De Filippis, C., Jirillo, A., Staffieri, A., & Blandamura, S. (2009). MASPIN's prognostic role in patients with advanced head and neck carcinoma treated with primary chemotherapy (carboplatin plus vinorelbine) and radiotherapy: Preliminary evidence. Acta Oto-Laryngologica, 129(7), 786-792. https://doi.org/10.1080/00016480802412789