MASPIN's prognostic role in patients with advanced head and neck carcinoma treated with primary chemotherapy (carboplatin plus vinorelbine) and radiotherapy: Preliminary evidence

Gino Marioni, Haralabos Koussis, Elena Gaio, Luciano Giacomelli, Andy Bertolin, Emiliano D'Alessandro, Annamaria Scola, Giancarlo Ottaviano, Cosimo De Filippis, Antonio Jirillo, Alberto Staffieri, Stella Blandamura

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Conclusions: Our very preliminary results support the hypothesis that MASPIN expression in primary head and neck squamous cell carcinoma (HNSCC) may be a valuable parameter for predicting patients' responses to a treatment based on carboplatin plus vinorelbine combined with radiotherapy. Objectives: The roles of induction chemotherapy and combined chemoradiotherapy in the treatment of locally advanced unresectable HNSCCs have evolved rapidly. MASPIN has a unique tumour-suppressing activity. Experimental evidence has shown that MASPIN suppresses tumour growth, angiogenesis, invasion and metastasis. We investigated the potential prognostic roles of MASPIN and p53 in a series of HNSCCs treated with carboplatin plus vinorelbine combined with radiotherapy. Patients and methods: Nineteen consecutive stage III or IV HNSCC patients were recruited. The treatment plan consisted of the administration of carboplatin on day 1 and vinorelbine on days 1 and 8. Four weeks later, carboplatin was administered concomitantly with radiation therapy. Expression of MASPIN and p53 was determined immunohistochemically in HNSCC diagnostic biopsies. Results: A significant inverse relation was found between MASPIN expression and cN staging (p=0.003). From a prognostic viewpoint, MASPIN expression was directly correlated with chemoradiotherapy response (p=0.041). Moreover, the log-rank test showed a significant relationship between higher MASPIN expression and longer disease-free survival (p=0.03), overall survival (p=0.006) and disease-specific survival (p=0.007).

Original languageEnglish
Pages (from-to)786-792
Number of pages7
JournalActa Oto-Laryngologica
Volume129
Issue number7
DOIs
Publication statusPublished - 2009

Fingerprint

Carboplatin
Neck
Radiotherapy
Head
Carcinoma
Drug Therapy
Chemoradiotherapy
Induction Chemotherapy
Survival
Disease-Free Survival
Neoplasms
Therapeutics
Neoplasm Metastasis
Biopsy
vinorelbine
Growth
Carcinoma, squamous cell of head and neck

Keywords

  • Carboplatin
  • Head and neck carcinoma
  • MASPIN
  • Prognosis
  • Radiotherapy
  • Vinorelbine

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

MASPIN's prognostic role in patients with advanced head and neck carcinoma treated with primary chemotherapy (carboplatin plus vinorelbine) and radiotherapy : Preliminary evidence. / Marioni, Gino; Koussis, Haralabos; Gaio, Elena; Giacomelli, Luciano; Bertolin, Andy; D'Alessandro, Emiliano; Scola, Annamaria; Ottaviano, Giancarlo; De Filippis, Cosimo; Jirillo, Antonio; Staffieri, Alberto; Blandamura, Stella.

In: Acta Oto-Laryngologica, Vol. 129, No. 7, 2009, p. 786-792.

Research output: Contribution to journalArticle

Marioni, G, Koussis, H, Gaio, E, Giacomelli, L, Bertolin, A, D'Alessandro, E, Scola, A, Ottaviano, G, De Filippis, C, Jirillo, A, Staffieri, A & Blandamura, S 2009, 'MASPIN's prognostic role in patients with advanced head and neck carcinoma treated with primary chemotherapy (carboplatin plus vinorelbine) and radiotherapy: Preliminary evidence', Acta Oto-Laryngologica, vol. 129, no. 7, pp. 786-792. https://doi.org/10.1080/00016480802412789
Marioni, Gino ; Koussis, Haralabos ; Gaio, Elena ; Giacomelli, Luciano ; Bertolin, Andy ; D'Alessandro, Emiliano ; Scola, Annamaria ; Ottaviano, Giancarlo ; De Filippis, Cosimo ; Jirillo, Antonio ; Staffieri, Alberto ; Blandamura, Stella. / MASPIN's prognostic role in patients with advanced head and neck carcinoma treated with primary chemotherapy (carboplatin plus vinorelbine) and radiotherapy : Preliminary evidence. In: Acta Oto-Laryngologica. 2009 ; Vol. 129, No. 7. pp. 786-792.
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T1 - MASPIN's prognostic role in patients with advanced head and neck carcinoma treated with primary chemotherapy (carboplatin plus vinorelbine) and radiotherapy

T2 - Preliminary evidence

AU - Marioni, Gino

AU - Koussis, Haralabos

AU - Gaio, Elena

AU - Giacomelli, Luciano

AU - Bertolin, Andy

AU - D'Alessandro, Emiliano

AU - Scola, Annamaria

AU - Ottaviano, Giancarlo

AU - De Filippis, Cosimo

AU - Jirillo, Antonio

AU - Staffieri, Alberto

AU - Blandamura, Stella

PY - 2009

Y1 - 2009

N2 - Conclusions: Our very preliminary results support the hypothesis that MASPIN expression in primary head and neck squamous cell carcinoma (HNSCC) may be a valuable parameter for predicting patients' responses to a treatment based on carboplatin plus vinorelbine combined with radiotherapy. Objectives: The roles of induction chemotherapy and combined chemoradiotherapy in the treatment of locally advanced unresectable HNSCCs have evolved rapidly. MASPIN has a unique tumour-suppressing activity. Experimental evidence has shown that MASPIN suppresses tumour growth, angiogenesis, invasion and metastasis. We investigated the potential prognostic roles of MASPIN and p53 in a series of HNSCCs treated with carboplatin plus vinorelbine combined with radiotherapy. Patients and methods: Nineteen consecutive stage III or IV HNSCC patients were recruited. The treatment plan consisted of the administration of carboplatin on day 1 and vinorelbine on days 1 and 8. Four weeks later, carboplatin was administered concomitantly with radiation therapy. Expression of MASPIN and p53 was determined immunohistochemically in HNSCC diagnostic biopsies. Results: A significant inverse relation was found between MASPIN expression and cN staging (p=0.003). From a prognostic viewpoint, MASPIN expression was directly correlated with chemoradiotherapy response (p=0.041). Moreover, the log-rank test showed a significant relationship between higher MASPIN expression and longer disease-free survival (p=0.03), overall survival (p=0.006) and disease-specific survival (p=0.007).

AB - Conclusions: Our very preliminary results support the hypothesis that MASPIN expression in primary head and neck squamous cell carcinoma (HNSCC) may be a valuable parameter for predicting patients' responses to a treatment based on carboplatin plus vinorelbine combined with radiotherapy. Objectives: The roles of induction chemotherapy and combined chemoradiotherapy in the treatment of locally advanced unresectable HNSCCs have evolved rapidly. MASPIN has a unique tumour-suppressing activity. Experimental evidence has shown that MASPIN suppresses tumour growth, angiogenesis, invasion and metastasis. We investigated the potential prognostic roles of MASPIN and p53 in a series of HNSCCs treated with carboplatin plus vinorelbine combined with radiotherapy. Patients and methods: Nineteen consecutive stage III or IV HNSCC patients were recruited. The treatment plan consisted of the administration of carboplatin on day 1 and vinorelbine on days 1 and 8. Four weeks later, carboplatin was administered concomitantly with radiation therapy. Expression of MASPIN and p53 was determined immunohistochemically in HNSCC diagnostic biopsies. Results: A significant inverse relation was found between MASPIN expression and cN staging (p=0.003). From a prognostic viewpoint, MASPIN expression was directly correlated with chemoradiotherapy response (p=0.041). Moreover, the log-rank test showed a significant relationship between higher MASPIN expression and longer disease-free survival (p=0.03), overall survival (p=0.006) and disease-specific survival (p=0.007).

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KW - Prognosis

KW - Radiotherapy

KW - Vinorelbine

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