TY - JOUR
T1 - Mass spectrometric identification of urinary and plasma metabolites of 6-(6'-carboxyhexyl)-7-n-hexyl-1,3-diazaspiro-[4,4]-nonan-2,4-dione, a new cytoprotective agent
AU - Benfenati, E.
AU - Fanelli, R.
AU - Bosone, E.
AU - Biffi, C.
AU - Caponi, R.
AU - Cianetti, M.
AU - Farina, P.
PY - 1991
Y1 - 1991
N2 - The compound IBI-P-01028, or R,S-cis-6-(6'-carboxyhexyl)-7-trans-n- hexyl-1,3-diazaspiro-[4-4]-nonan-2,4-dione, is a new cytoprotective agent under development. To study the metabolites of this compound in laboratory animals, we administered it to dogs and rats, and analyzed extracts from dog and rat urine, and from dog plasma, by GC-MS. The metabolic profiles were different in the rat and dog. In the dog (plasma and urine), one metabolite was found, and in the rat urine two other metabolites were found. The unmetabolized drug was found only in the dog plasma and urine.
AB - The compound IBI-P-01028, or R,S-cis-6-(6'-carboxyhexyl)-7-trans-n- hexyl-1,3-diazaspiro-[4-4]-nonan-2,4-dione, is a new cytoprotective agent under development. To study the metabolites of this compound in laboratory animals, we administered it to dogs and rats, and analyzed extracts from dog and rat urine, and from dog plasma, by GC-MS. The metabolic profiles were different in the rat and dog. In the dog (plasma and urine), one metabolite was found, and in the rat urine two other metabolites were found. The unmetabolized drug was found only in the dog plasma and urine.
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M3 - Article
C2 - 1686235
AN - SCOPUS:0025995957
VL - 19
SP - 913
EP - 916
JO - Drug Metabolism and Disposition
JF - Drug Metabolism and Disposition
SN - 0090-9556
IS - 5
ER -