Massive activation of immune cells with an intact t cell repertoire in acute human immunodeficiency virus syndrome

Andrea Cossarizza, Claudio Ortolani, Cristina Mussini, Vanni Borghi, Giovanni Guaraldi, Nicola Mongiardo, Enrica Bellesia, Maria Grazia Franceschini, Bruno De Rienzo, Claudio Franceschi

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Abstract

In 8 patients with symptomatic, acute primary infection with human immunodeficiency virus (HIV), a dramatic and persistent decrease in CD4+ lymphocytes was seen, accompanied by a marked increase in activated/memory CD8+ T cells (CD38+CD45RO+HLA-DR+with high amounts of cell adhesion molecules), which represented most circulating lymphocytes, but no gross alterations in Vγ T cell repertoire. Extremely high plasma levels of proinflammatory cytokines were observed. Three patients were followed for 2-3 years: The number of CD4+ cells, extremely low at first, increased significantly in a few months but decreased rapidly after a short stable period. Cytotoxic T lymphocytes bearing markers of immunologic activation/memory could play an important role in the earliest phases of the disease. It remains to be established how such a dramatic onset could determine the rapid progression of the infection that seems characteristic of patients with acute HIV syndrome.

Original languageEnglish
Pages (from-to)105-112
Number of pages8
JournalJournal of Infectious Diseases
Volume172
Issue number1
DOIs
Publication statusPublished - 1995

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ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Immunology
  • Public Health, Environmental and Occupational Health

Cite this

Cossarizza, A., Ortolani, C., Mussini, C., Borghi, V., Guaraldi, G., Mongiardo, N., Bellesia, E., Franceschini, M. G., De Rienzo, B., & Franceschi, C. (1995). Massive activation of immune cells with an intact t cell repertoire in acute human immunodeficiency virus syndrome. Journal of Infectious Diseases, 172(1), 105-112. https://doi.org/10.1093/infdis/172.1.105