Massive hepatic angiomyolipoma in a young woman with tuberous sclerosis complex: Significant clinical improvement during tamoxifen treatment

Ilaria Lenci, Mario Angelico, Giuseppe Tisone, Antonio Orlacchio, Giampiero Palmieri, Mariangela Pinci, Roberta Bombardieri, Paolo Curatolo

Research output: Contribution to journalArticle

Abstract

Background/Aims: Isolated liver angiomyolipomas (AMLs) occur in about 40% of TSC patients. Because of their slow growth, these tumors are often asymptomatic. Since AMLs express estrogen and progesteron receptors we suggest the possible benefits of tamoxifen for the treatment of liver AMLs. Methods: We report the case of a 26-year-old female affected by tuberous sclerosis (TSC2) with cerebral, renal and hepatic involvement admitted to the Liver Unit for severe malnutrition, anorexia and abdominal pain. MRI showed a grossly enlarged liver, causing severe gastric compression. The liver was entirely filled with multiple nodular lesions of different sizes. Liver biopsy showed tumoral tissue with microscopic and ultrastructural features of angiomyolipoma. All liver function tests were repeatedly normal. Prior to considering the patient for partial hepatectomy, she was administered tamoxifen (20 mg b.i.d). Results: After 6 months of tamoxifen treatment a greatly improved quality of life and a significant weight gain were observed. After 12 months the clinical conditions further improved and the MRI showed a significant reduction of the largest lesion with a liquid central area and a diminished compression of the stomach. Conclusions: This is to our knowledge the first report in which tamoxifen has been successfully used in a TSC patient with multiple liver angiomyolipomas.

Original languageEnglish
Pages (from-to)1026-1029
Number of pages4
JournalJournal of Hepatology
Volume48
Issue number6
DOIs
Publication statusPublished - Jun 2008

Keywords

  • Angiomyolipoma
  • Tamoxifen
  • Tuberous sclerosis complex

ASJC Scopus subject areas

  • Gastroenterology

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