Massive interstitial fibrosis precipitated by pneumonia in a woman with mixed connective tissue disease

Giovanni Passalacqua, M. Sivori, A. De Maria, R. Quaglia, E. Fulcheri, S. Lanata, A. Scordamaglia

Research output: Contribution to journalArticlepeer-review

Abstract

The interstitial involvement of lungs during systemic connective tissue diseases is well known: most of connective tissue diseases can evolve, at various degree, into diffuse interstitial fibrosis. The variable clinical presentations of these diseases can lead to underestimate the severity of lung involvement. We describe the case of a 64-year-old woman with ascertained but paucisymptomatic mixed connective tissue disease. Although no sign of previous pulmonary involvement was present, the onset of pneumonia rapidly precipitated the respiratory function, leading to ARDS and subsequent death. The autopsy disclosed a massive and severe interstitial fibrosis, with superimposed pneumonia on resolution. We suggest that patients suffering from systemic connective tissue diseases should be carefully ynonitored for lung involvement.

Original languageEnglish
Pages (from-to)116-118
Number of pages3
JournalItalian Journal of Allergy and Clinical Immunology
Volume15
Issue number3
Publication statusPublished - Sep 2005

Keywords

  • Interstitial fibrosis
  • Mixed connective tissue disease
  • Pneumonia

ASJC Scopus subject areas

  • Immunology and Allergy

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