Mast cell density, angiogenesis, blood clotting, and prognosis in women with advanced ovarian cancer

John K. Chan, Alessandra Magistris, Vera Loizzi, Fritz Lin, Joanne Rutgers, Kathryn Osann, Philip J. DiSaia, Michael Samoszuk

Research output: Contribution to journalArticlepeer-review

Abstract

Objective. To determine clinical or biological associations between mast cell density, blood clotting, angiogenesis, and survival of patients with advanced ovarian cancer. Methods. Tumor tissue sections were assessed for mast cell density by staining for mast cell tryptase, blood clotting by staining of thrombosed blood vessels, and angiogenesis by CD34 expression. Chi-square, Kaplan-Meier, and Cox proportional hazard statistical analyses were used. Results. 44 women with stage III-IV ovarian cancers had tumor blocks available for immunohistochemical analysis. Higher mean vessel density (MVD) (>11 vessels/400× field) predicted for better survival than lower MVD (≤11 vessels/400× field) (P = 0.004). Women whose tumors had low levels of peri-tumoral mast cell infiltration had a mean survival of 40.6 months compared to 50.6 months in those whose tumors had high levels (P = 0.47). Tumors with higher MVD and high peri-tumoral mast cell infiltration had a mean survival of 80.3 months compared to 37.8 months in those with low mast cell density or low MVD (P = 0.015). Patients with tumors showing a low degree of blood clotting had a mean survival of 45.5 compared to 45.1 months in those with tumors showing a high degree of blood clotting (P = 0.91). There was no significant association between angiogenesis and mast cell density (P = 0.123). In multivariate analysis, higher MVD remained as a significant prognostic factor for improved survival after adjusting for clotting and mast cell density. Conclusions. Our data suggest that peri-tumoral mast cell infiltration in tumors with high MVD predicts for improved survival in women with advanced epithelial ovarian cancer.

Original languageEnglish
Pages (from-to)20-25
Number of pages6
JournalGynecologic Oncology
Volume99
Issue number1
DOIs
Publication statusPublished - Oct 2005

Keywords

  • Mast cell tryptase
  • Microvessel density
  • Thrombosed blood vessel

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

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