Mast cell disorders, melanoma and pancreatic carcinoma: From a clinical observation to a brief review of the literature

Giovanni Paolino, Maria Belmonte, Stefania Trasarti, Michelina Santopietro, Luisa Bizzoni, Mara Riminucci, Luisa Cardarelli, Emilia Iannella, Marcello Albanesi, Elisa Moliterni, Dario Didona, Stefano Calvieri, Robin Foà, Fiorina Giona

Research output: Contribution to journalReview articlepeer-review

Abstract

Mastocytosis can be associated with other clonal or non-clonal hematologic diseases as well as a variety of non-hematologic malignancies. A 75-year-old Caucasian male patient was referred to us with a 5-month history of neutrophilic leukocytosis and mild splenomegaly. He had developed a cutaneous melanoma sixteen years ago. According to the clinical and pathological features, a final diagnosis of systemic mastocytosis was established. The patient started treatment with interferon-α at a dose of 3 MIU/day, combined with low doses of prednisone. We observed a rapid disappearance of symptoms. Unfortunately, after 3 months a diagnosis of pancreatic adenocarcinoma was established. A review of the literature suggests that mastocytes could have a pivotal role in several malignancies. Different chemokines, mitogenic factors, chemical mediators of inflammation, and specific gene mutations could explain the association between mastocytosis and other hematologic and non-hematologic disorders.

Original languageEnglish
Pages (from-to)112-119
Number of pages8
JournalActa Dermatovenerologica Croatica
Volume25
Issue number2
Publication statusPublished - Jan 1 2017

Keywords

  • Mastocytosis
  • Melanoma
  • Pancreatic neoplasms
  • Tryptases

ASJC Scopus subject areas

  • Dermatology
  • Infectious Diseases

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