TY - JOUR
T1 - Mast cell disorders, melanoma and pancreatic carcinoma
T2 - From a clinical observation to a brief review of the literature
AU - Paolino, Giovanni
AU - Belmonte, Maria
AU - Trasarti, Stefania
AU - Santopietro, Michelina
AU - Bizzoni, Luisa
AU - Riminucci, Mara
AU - Cardarelli, Luisa
AU - Iannella, Emilia
AU - Albanesi, Marcello
AU - Moliterni, Elisa
AU - Didona, Dario
AU - Calvieri, Stefano
AU - Foà, Robin
AU - Giona, Fiorina
PY - 2017/1/1
Y1 - 2017/1/1
N2 - Mastocytosis can be associated with other clonal or non-clonal hematologic diseases as well as a variety of non-hematologic malignancies. A 75-year-old Caucasian male patient was referred to us with a 5-month history of neutrophilic leukocytosis and mild splenomegaly. He had developed a cutaneous melanoma sixteen years ago. According to the clinical and pathological features, a final diagnosis of systemic mastocytosis was established. The patient started treatment with interferon-α at a dose of 3 MIU/day, combined with low doses of prednisone. We observed a rapid disappearance of symptoms. Unfortunately, after 3 months a diagnosis of pancreatic adenocarcinoma was established. A review of the literature suggests that mastocytes could have a pivotal role in several malignancies. Different chemokines, mitogenic factors, chemical mediators of inflammation, and specific gene mutations could explain the association between mastocytosis and other hematologic and non-hematologic disorders.
AB - Mastocytosis can be associated with other clonal or non-clonal hematologic diseases as well as a variety of non-hematologic malignancies. A 75-year-old Caucasian male patient was referred to us with a 5-month history of neutrophilic leukocytosis and mild splenomegaly. He had developed a cutaneous melanoma sixteen years ago. According to the clinical and pathological features, a final diagnosis of systemic mastocytosis was established. The patient started treatment with interferon-α at a dose of 3 MIU/day, combined with low doses of prednisone. We observed a rapid disappearance of symptoms. Unfortunately, after 3 months a diagnosis of pancreatic adenocarcinoma was established. A review of the literature suggests that mastocytes could have a pivotal role in several malignancies. Different chemokines, mitogenic factors, chemical mediators of inflammation, and specific gene mutations could explain the association between mastocytosis and other hematologic and non-hematologic disorders.
KW - Mastocytosis
KW - Melanoma
KW - Pancreatic neoplasms
KW - Tryptases
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M3 - Review article
C2 - 28871925
AN - SCOPUS:85025130060
VL - 25
SP - 112
EP - 119
JO - Acta Dermatovenerologica Croatica
JF - Acta Dermatovenerologica Croatica
SN - 1330-027X
IS - 2
ER -