Mast cell heterogeneity in B-cell non-Hodgkin's lymphomas: An ultrastructural study

Enrico Crivellato, Beatrice Nico, Angelo Vacca, Franco Dammacco, Domenico Ribatti

Research output: Contribution to journalArticlepeer-review

Abstract

Mast cells (MC) are critical for a number of pathological conditions, including acute and chronic inflammation and tumor angiogenesis. We have previously demonstrated that in B-cell non-Hodgkin's lymphoma (B-NHL) angiogenesis is correlated with total methachromatic and tryptase-positive MC and that both counts increase in step with the increase in malignancy [1,2], whereas the role of MC in malignant lymph nodes is not fully clear. An extensive ultrastructural study has been made of representative samples of 30 B-NHL and 10 benign lymphadenopathies. A heterogeneous population of MC characterized by the presence of granules with a semilunar aspect and containing scrolls was observed. The former are the expression of a slow but progressive release of angiogenic factors due to chronic, progressive stimulation of MC degranulation, while the latter contain tryptase, an angiogenic factor. These two ultrastructural data confirm the important role played by MC in the angiogenesis associated with progression in B-NHL.

Original languageEnglish
Pages (from-to)2201-2205
Number of pages5
JournalLeukemia and Lymphoma
Volume43
Issue number11
DOIs
Publication statusPublished - Nov 1 2002

Keywords

  • Angiogenesis
  • B-NHL
  • Tryptase
  • Ultrastructure

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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