Mast cell positivity to tryptase correlates with metastatic lymph nodes in gastrointestinal cancer patients treated surgically

Michele Ammendola, Rosario Sacco, Giuseppe Donato, Valeria Zuccalà, Emilio Russo, Maria Luposella, Giuseppina Vescio, Antonia Rizzuto, Rosa Patruno, Giovambattista De Sarro, Severino Montemurro, Giuseppe Sammarco, Girolamo Ranieri

Research output: Contribution to journalArticle

Abstract

Background: Angiogenesis has been found to be a reliable prognostic indicator for several types of malignancies. Tryptase is a serine protease stored in mast cell (MC) granules, which plays a role in tumor angiogenesis. MCs can release tryptase following c-Kit receptor activation. Method: In this study, immunohistochemistry, image analysis methods and clinical aspects were employed in a series of 41 gastrointestinal cancer patients with stage T 3-4N2a-bM0 (by the American Joint Committee on Cancer, AJCC, for colorectal cancer, 7th edition) and T3N 2-3M0 (by AJCC for gastric cancer, 7th edition) to evaluate the possible correlation between MCs positive to tryptase (MCPT) in tumor tissue and the number of metastatic lymph nodes harvested. Results: Data demonstrated a positive correlation between MCPT in tumor tissue and the number of metastatic lymph nodes; the validity of these data needs confirmation in larger patient cohorts. Conclusion: This is the first report considering MCPT in tumor tissue as a potential tool for a valid indication of the type of surgical treatment and its radicality, and it might be considered for the prognosis of patients before radical surgical treatment. Our pilot data need confirmation in a larger patient cohort.

Original languageEnglish
Pages (from-to)111-116
Number of pages6
JournalOncology
Volume85
Issue number2
DOIs
Publication statusPublished - Aug 2013

Fingerprint

Tryptases
Gastrointestinal Neoplasms
Mast Cells
Lymph Nodes
Neoplasms
Proto-Oncogene Proteins c-kit
Serine Proteases
Stomach Neoplasms
Colorectal Neoplasms
Immunohistochemistry
Therapeutics

Keywords

  • Angiogenesis
  • Gastrointestinal cancer
  • Predictive factor
  • Prognosticator
  • Tryptase

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Mast cell positivity to tryptase correlates with metastatic lymph nodes in gastrointestinal cancer patients treated surgically. / Ammendola, Michele; Sacco, Rosario; Donato, Giuseppe; Zuccalà, Valeria; Russo, Emilio; Luposella, Maria; Vescio, Giuseppina; Rizzuto, Antonia; Patruno, Rosa; De Sarro, Giovambattista; Montemurro, Severino; Sammarco, Giuseppe; Ranieri, Girolamo.

In: Oncology, Vol. 85, No. 2, 08.2013, p. 111-116.

Research output: Contribution to journalArticle

Ammendola, M, Sacco, R, Donato, G, Zuccalà, V, Russo, E, Luposella, M, Vescio, G, Rizzuto, A, Patruno, R, De Sarro, G, Montemurro, S, Sammarco, G & Ranieri, G 2013, 'Mast cell positivity to tryptase correlates with metastatic lymph nodes in gastrointestinal cancer patients treated surgically', Oncology, vol. 85, no. 2, pp. 111-116. https://doi.org/10.1159/000351145
Ammendola, Michele ; Sacco, Rosario ; Donato, Giuseppe ; Zuccalà, Valeria ; Russo, Emilio ; Luposella, Maria ; Vescio, Giuseppina ; Rizzuto, Antonia ; Patruno, Rosa ; De Sarro, Giovambattista ; Montemurro, Severino ; Sammarco, Giuseppe ; Ranieri, Girolamo. / Mast cell positivity to tryptase correlates with metastatic lymph nodes in gastrointestinal cancer patients treated surgically. In: Oncology. 2013 ; Vol. 85, No. 2. pp. 111-116.
@article{22932bdcf5ae4bcba763bf72b2bb6037,
title = "Mast cell positivity to tryptase correlates with metastatic lymph nodes in gastrointestinal cancer patients treated surgically",
abstract = "Background: Angiogenesis has been found to be a reliable prognostic indicator for several types of malignancies. Tryptase is a serine protease stored in mast cell (MC) granules, which plays a role in tumor angiogenesis. MCs can release tryptase following c-Kit receptor activation. Method: In this study, immunohistochemistry, image analysis methods and clinical aspects were employed in a series of 41 gastrointestinal cancer patients with stage T 3-4N2a-bM0 (by the American Joint Committee on Cancer, AJCC, for colorectal cancer, 7th edition) and T3N 2-3M0 (by AJCC for gastric cancer, 7th edition) to evaluate the possible correlation between MCs positive to tryptase (MCPT) in tumor tissue and the number of metastatic lymph nodes harvested. Results: Data demonstrated a positive correlation between MCPT in tumor tissue and the number of metastatic lymph nodes; the validity of these data needs confirmation in larger patient cohorts. Conclusion: This is the first report considering MCPT in tumor tissue as a potential tool for a valid indication of the type of surgical treatment and its radicality, and it might be considered for the prognosis of patients before radical surgical treatment. Our pilot data need confirmation in a larger patient cohort.",
keywords = "Angiogenesis, Gastrointestinal cancer, Predictive factor, Prognosticator, Tryptase",
author = "Michele Ammendola and Rosario Sacco and Giuseppe Donato and Valeria Zuccal{\`a} and Emilio Russo and Maria Luposella and Giuseppina Vescio and Antonia Rizzuto and Rosa Patruno and {De Sarro}, Giovambattista and Severino Montemurro and Giuseppe Sammarco and Girolamo Ranieri",
year = "2013",
month = "8",
doi = "10.1159/000351145",
language = "English",
volume = "85",
pages = "111--116",
journal = "Oncology",
issn = "0030-2414",
publisher = "UBM Medica Healthcare Publications",
number = "2",

}

TY - JOUR

T1 - Mast cell positivity to tryptase correlates with metastatic lymph nodes in gastrointestinal cancer patients treated surgically

AU - Ammendola, Michele

AU - Sacco, Rosario

AU - Donato, Giuseppe

AU - Zuccalà, Valeria

AU - Russo, Emilio

AU - Luposella, Maria

AU - Vescio, Giuseppina

AU - Rizzuto, Antonia

AU - Patruno, Rosa

AU - De Sarro, Giovambattista

AU - Montemurro, Severino

AU - Sammarco, Giuseppe

AU - Ranieri, Girolamo

PY - 2013/8

Y1 - 2013/8

N2 - Background: Angiogenesis has been found to be a reliable prognostic indicator for several types of malignancies. Tryptase is a serine protease stored in mast cell (MC) granules, which plays a role in tumor angiogenesis. MCs can release tryptase following c-Kit receptor activation. Method: In this study, immunohistochemistry, image analysis methods and clinical aspects were employed in a series of 41 gastrointestinal cancer patients with stage T 3-4N2a-bM0 (by the American Joint Committee on Cancer, AJCC, for colorectal cancer, 7th edition) and T3N 2-3M0 (by AJCC for gastric cancer, 7th edition) to evaluate the possible correlation between MCs positive to tryptase (MCPT) in tumor tissue and the number of metastatic lymph nodes harvested. Results: Data demonstrated a positive correlation between MCPT in tumor tissue and the number of metastatic lymph nodes; the validity of these data needs confirmation in larger patient cohorts. Conclusion: This is the first report considering MCPT in tumor tissue as a potential tool for a valid indication of the type of surgical treatment and its radicality, and it might be considered for the prognosis of patients before radical surgical treatment. Our pilot data need confirmation in a larger patient cohort.

AB - Background: Angiogenesis has been found to be a reliable prognostic indicator for several types of malignancies. Tryptase is a serine protease stored in mast cell (MC) granules, which plays a role in tumor angiogenesis. MCs can release tryptase following c-Kit receptor activation. Method: In this study, immunohistochemistry, image analysis methods and clinical aspects were employed in a series of 41 gastrointestinal cancer patients with stage T 3-4N2a-bM0 (by the American Joint Committee on Cancer, AJCC, for colorectal cancer, 7th edition) and T3N 2-3M0 (by AJCC for gastric cancer, 7th edition) to evaluate the possible correlation between MCs positive to tryptase (MCPT) in tumor tissue and the number of metastatic lymph nodes harvested. Results: Data demonstrated a positive correlation between MCPT in tumor tissue and the number of metastatic lymph nodes; the validity of these data needs confirmation in larger patient cohorts. Conclusion: This is the first report considering MCPT in tumor tissue as a potential tool for a valid indication of the type of surgical treatment and its radicality, and it might be considered for the prognosis of patients before radical surgical treatment. Our pilot data need confirmation in a larger patient cohort.

KW - Angiogenesis

KW - Gastrointestinal cancer

KW - Predictive factor

KW - Prognosticator

KW - Tryptase

UR - http://www.scopus.com/inward/record.url?scp=84880405739&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880405739&partnerID=8YFLogxK

U2 - 10.1159/000351145

DO - 10.1159/000351145

M3 - Article

C2 - 23887206

AN - SCOPUS:84880405739

VL - 85

SP - 111

EP - 116

JO - Oncology

JF - Oncology

SN - 0030-2414

IS - 2

ER -