Abstract
Background: Angiogenesis has been found to be a reliable prognostic indicator for several types of malignancies. Tryptase is a serine protease stored in mast cell (MC) granules, which plays a role in tumor angiogenesis. MCs can release tryptase following c-Kit receptor activation. Method: In this study, immunohistochemistry, image analysis methods and clinical aspects were employed in a series of 41 gastrointestinal cancer patients with stage T 3-4N2a-bM0 (by the American Joint Committee on Cancer, AJCC, for colorectal cancer, 7th edition) and T3N 2-3M0 (by AJCC for gastric cancer, 7th edition) to evaluate the possible correlation between MCs positive to tryptase (MCPT) in tumor tissue and the number of metastatic lymph nodes harvested. Results: Data demonstrated a positive correlation between MCPT in tumor tissue and the number of metastatic lymph nodes; the validity of these data needs confirmation in larger patient cohorts. Conclusion: This is the first report considering MCPT in tumor tissue as a potential tool for a valid indication of the type of surgical treatment and its radicality, and it might be considered for the prognosis of patients before radical surgical treatment. Our pilot data need confirmation in a larger patient cohort.
| Original language | English |
|---|---|
| Pages (from-to) | 111-116 |
| Number of pages | 6 |
| Journal | Oncology |
| Volume | 85 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - Aug 2013 |
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Keywords
- Angiogenesis
- Gastrointestinal cancer
- Predictive factor
- Prognosticator
- Tryptase
ASJC Scopus subject areas
- Cancer Research
- Oncology
Cite this
Mast cell positivity to tryptase correlates with metastatic lymph nodes in gastrointestinal cancer patients treated surgically. / Ammendola, Michele; Sacco, Rosario; Donato, Giuseppe; Zuccalà, Valeria; Russo, Emilio; Luposella, Maria; Vescio, Giuseppina; Rizzuto, Antonia; Patruno, Rosa; De Sarro, Giovambattista; Montemurro, Severino; Sammarco, Giuseppe; Ranieri, Girolamo.
In: Oncology, Vol. 85, No. 2, 08.2013, p. 111-116.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mast cell positivity to tryptase correlates with metastatic lymph nodes in gastrointestinal cancer patients treated surgically
AU - Ammendola, Michele
AU - Sacco, Rosario
AU - Donato, Giuseppe
AU - Zuccalà, Valeria
AU - Russo, Emilio
AU - Luposella, Maria
AU - Vescio, Giuseppina
AU - Rizzuto, Antonia
AU - Patruno, Rosa
AU - De Sarro, Giovambattista
AU - Montemurro, Severino
AU - Sammarco, Giuseppe
AU - Ranieri, Girolamo
PY - 2013/8
Y1 - 2013/8
N2 - Background: Angiogenesis has been found to be a reliable prognostic indicator for several types of malignancies. Tryptase is a serine protease stored in mast cell (MC) granules, which plays a role in tumor angiogenesis. MCs can release tryptase following c-Kit receptor activation. Method: In this study, immunohistochemistry, image analysis methods and clinical aspects were employed in a series of 41 gastrointestinal cancer patients with stage T 3-4N2a-bM0 (by the American Joint Committee on Cancer, AJCC, for colorectal cancer, 7th edition) and T3N 2-3M0 (by AJCC for gastric cancer, 7th edition) to evaluate the possible correlation between MCs positive to tryptase (MCPT) in tumor tissue and the number of metastatic lymph nodes harvested. Results: Data demonstrated a positive correlation between MCPT in tumor tissue and the number of metastatic lymph nodes; the validity of these data needs confirmation in larger patient cohorts. Conclusion: This is the first report considering MCPT in tumor tissue as a potential tool for a valid indication of the type of surgical treatment and its radicality, and it might be considered for the prognosis of patients before radical surgical treatment. Our pilot data need confirmation in a larger patient cohort.
AB - Background: Angiogenesis has been found to be a reliable prognostic indicator for several types of malignancies. Tryptase is a serine protease stored in mast cell (MC) granules, which plays a role in tumor angiogenesis. MCs can release tryptase following c-Kit receptor activation. Method: In this study, immunohistochemistry, image analysis methods and clinical aspects were employed in a series of 41 gastrointestinal cancer patients with stage T 3-4N2a-bM0 (by the American Joint Committee on Cancer, AJCC, for colorectal cancer, 7th edition) and T3N 2-3M0 (by AJCC for gastric cancer, 7th edition) to evaluate the possible correlation between MCs positive to tryptase (MCPT) in tumor tissue and the number of metastatic lymph nodes harvested. Results: Data demonstrated a positive correlation between MCPT in tumor tissue and the number of metastatic lymph nodes; the validity of these data needs confirmation in larger patient cohorts. Conclusion: This is the first report considering MCPT in tumor tissue as a potential tool for a valid indication of the type of surgical treatment and its radicality, and it might be considered for the prognosis of patients before radical surgical treatment. Our pilot data need confirmation in a larger patient cohort.
KW - Angiogenesis
KW - Gastrointestinal cancer
KW - Predictive factor
KW - Prognosticator
KW - Tryptase
UR - http://www.scopus.com/inward/record.url?scp=84880405739&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880405739&partnerID=8YFLogxK
U2 - 10.1159/000351145
DO - 10.1159/000351145
M3 - Article
C2 - 23887206
AN - SCOPUS:84880405739
VL - 85
SP - 111
EP - 116
JO - Oncology
JF - Oncology
SN - 0030-2414
IS - 2
ER -