Mast cells and cancer: a review of literature

Giovanni Paolino, Paola Corsetti, Elisa Moliterni, Serena Corsetti, Dario Didona, Marcello Albanesi, Carlo Mattozzi, Paolo Lido, Stefano Calvieri

Research output: Contribution to journalArticle

Abstract

Mast cells (MCs) are a potent proangiogenic factor in tumors, they product several pro- angiogenic factors such as fibroblast growth factor 2 (FGF-2), vascular epithelial growth factor (VEGF), tryptase and chymase. Tryptase is a serine protease classified as α-tryptase and β-tryptase, both produced by MCs. Tryptase degrades the tissues, playing an important role in angiogenesis and in the development of metastases. Serum tryptase increases with age, with increased damage to cells and risk of developing a malignancy and it could be considered the expression of a fundamental role of MCs in tumor growth or, on the contrary, in the antitumor response. Many biomarkers have been developed in clinical practice for improving diagnosis and prognosis of some neoplasms. Elevated tryptase levels are found in subgroups of patients with haematologic and solid cancers. In the current review, we want to update the perspectives of tryptase as a potential biomarker in daily practice in different neoplasms.

Original languageEnglish
JournalGiornale Italiano di Dermatologia e Venereologia
DOIs
Publication statusE-pub ahead of print - Nov 30 2017

Fingerprint

Tryptases
Mast Cells
Neoplasms
Biomarkers
Chymases
Angiogenesis Inducing Agents
Serine Proteases
Fibroblast Growth Factor 2
Blood Vessels
Intercellular Signaling Peptides and Proteins
Neoplasm Metastasis

Cite this

Mast cells and cancer : a review of literature. / Paolino, Giovanni; Corsetti, Paola; Moliterni, Elisa; Corsetti, Serena; Didona, Dario; Albanesi, Marcello; Mattozzi, Carlo; Lido, Paolo; Calvieri, Stefano.

In: Giornale Italiano di Dermatologia e Venereologia, 30.11.2017.

Research output: Contribution to journalArticle

Paolino, G, Corsetti, P, Moliterni, E, Corsetti, S, Didona, D, Albanesi, M, Mattozzi, C, Lido, P & Calvieri, S 2017, 'Mast cells and cancer: a review of literature', Giornale Italiano di Dermatologia e Venereologia. https://doi.org/10.23736/S0392-0488.17.05818-7
Paolino, Giovanni ; Corsetti, Paola ; Moliterni, Elisa ; Corsetti, Serena ; Didona, Dario ; Albanesi, Marcello ; Mattozzi, Carlo ; Lido, Paolo ; Calvieri, Stefano. / Mast cells and cancer : a review of literature. In: Giornale Italiano di Dermatologia e Venereologia. 2017.
@article{5ce2d81b68014b22a05c65ee86055353,
title = "Mast cells and cancer: a review of literature",
abstract = "Mast cells (MCs) are a potent proangiogenic factor in tumors, they product several pro- angiogenic factors such as fibroblast growth factor 2 (FGF-2), vascular epithelial growth factor (VEGF), tryptase and chymase. Tryptase is a serine protease classified as α-tryptase and β-tryptase, both produced by MCs. Tryptase degrades the tissues, playing an important role in angiogenesis and in the development of metastases. Serum tryptase increases with age, with increased damage to cells and risk of developing a malignancy and it could be considered the expression of a fundamental role of MCs in tumor growth or, on the contrary, in the antitumor response. Many biomarkers have been developed in clinical practice for improving diagnosis and prognosis of some neoplasms. Elevated tryptase levels are found in subgroups of patients with haematologic and solid cancers. In the current review, we want to update the perspectives of tryptase as a potential biomarker in daily practice in different neoplasms.",
author = "Giovanni Paolino and Paola Corsetti and Elisa Moliterni and Serena Corsetti and Dario Didona and Marcello Albanesi and Carlo Mattozzi and Paolo Lido and Stefano Calvieri",
year = "2017",
month = "11",
day = "30",
doi = "10.23736/S0392-0488.17.05818-7",
language = "English",
journal = "Giornale Italiano di Dermatologia e Venereologia",
issn = "0392-0488",
publisher = "Edizioni Minerva Medica S.p.A.",

}

TY - JOUR

T1 - Mast cells and cancer

T2 - a review of literature

AU - Paolino, Giovanni

AU - Corsetti, Paola

AU - Moliterni, Elisa

AU - Corsetti, Serena

AU - Didona, Dario

AU - Albanesi, Marcello

AU - Mattozzi, Carlo

AU - Lido, Paolo

AU - Calvieri, Stefano

PY - 2017/11/30

Y1 - 2017/11/30

N2 - Mast cells (MCs) are a potent proangiogenic factor in tumors, they product several pro- angiogenic factors such as fibroblast growth factor 2 (FGF-2), vascular epithelial growth factor (VEGF), tryptase and chymase. Tryptase is a serine protease classified as α-tryptase and β-tryptase, both produced by MCs. Tryptase degrades the tissues, playing an important role in angiogenesis and in the development of metastases. Serum tryptase increases with age, with increased damage to cells and risk of developing a malignancy and it could be considered the expression of a fundamental role of MCs in tumor growth or, on the contrary, in the antitumor response. Many biomarkers have been developed in clinical practice for improving diagnosis and prognosis of some neoplasms. Elevated tryptase levels are found in subgroups of patients with haematologic and solid cancers. In the current review, we want to update the perspectives of tryptase as a potential biomarker in daily practice in different neoplasms.

AB - Mast cells (MCs) are a potent proangiogenic factor in tumors, they product several pro- angiogenic factors such as fibroblast growth factor 2 (FGF-2), vascular epithelial growth factor (VEGF), tryptase and chymase. Tryptase is a serine protease classified as α-tryptase and β-tryptase, both produced by MCs. Tryptase degrades the tissues, playing an important role in angiogenesis and in the development of metastases. Serum tryptase increases with age, with increased damage to cells and risk of developing a malignancy and it could be considered the expression of a fundamental role of MCs in tumor growth or, on the contrary, in the antitumor response. Many biomarkers have been developed in clinical practice for improving diagnosis and prognosis of some neoplasms. Elevated tryptase levels are found in subgroups of patients with haematologic and solid cancers. In the current review, we want to update the perspectives of tryptase as a potential biomarker in daily practice in different neoplasms.

U2 - 10.23736/S0392-0488.17.05818-7

DO - 10.23736/S0392-0488.17.05818-7

M3 - Article

C2 - 29192477

JO - Giornale Italiano di Dermatologia e Venereologia

JF - Giornale Italiano di Dermatologia e Venereologia

SN - 0392-0488

ER -