Mast cells and macrophages exert beneficial and detrimental effects on tumor progression and angiogenesis

Domenico Ribatti

Research output: Contribution to journalArticlepeer-review

Abstract

Mast cells and macrophages are critical regulators of inflammation and immunological response in the tumor microenvironment. Increased number of mast cells and macrophages have been reported to correlate with poor prognosis in numerous solid and hematological tumors. In contrast to their pro-tumorigenic role, mast cells and macrophages have shown also anti-tumorigenic effect in certain malignancies, for example by supporting cancer rejection. Thus, mast cells and macrophages can exert both detrimental and beneficial effects on tumor progression. Mast cell- and macrophages-derived growth factors able to promote tumor development and angiogenesis include TNF-α, TGF-β1, FGF-2, VEGF, PDGF, IL-8, osteopontin, and NGF. On the contrary, mast cell- and macrophages-produced cytokines that may participate in anti-tumor response include IL-1, IL-2, IL-4, IL-10, and IFN-γ. It is to note that mast cells and macrophages may also show beneficial and detrimental effects in the same cancer depending on the tumor stage.

Original languageEnglish
Pages (from-to)83-88
Number of pages6
JournalImmunology Letters
Volume152
Issue number2
DOIs
Publication statusPublished - 2013

Keywords

  • Angiogenesis
  • Macrophages
  • Mast cells
  • Tumor progression

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Medicine(all)

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