Mast cells and tumour angiogenesis: New insight from experimental carcinogenesis

Enrico Crivellato, Beatrice Nico, Domenico Ribatti

Research output: Contribution to journalArticle

77 Citations (Scopus)

Abstract

Histopathologic examination and clinical observations of solid and haematological malignancies indicates mast cells as key host cells in the tumour infiltrate, with important consequence on tumour-associated angiogenesis and tumour growth. Data suggest indeed that tumour-infiltrating mast cells may exert a prominent function in the angiogenic "switch", which is essential for the progression of early tumours. The experimental approach has substantially increased our understanding of the role of tumour-infiltrating mast cells in the process of angiogenesis that accompanies tumour development. This review will focus on the crucial contribution of mast cells in promoting tumour neovascularization as it emerges from the most recent observations of experimental carcinogenesis in in vivo and in vitro models.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalCancer Letters
Volume269
Issue number1
DOIs
Publication statusPublished - Sep 28 2008

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Mast Cells
Carcinogenesis
Neoplasms
Hematologic Neoplasms
Growth

Keywords

  • Angiogenesis
  • Mast cells
  • Tumour

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Mast cells and tumour angiogenesis : New insight from experimental carcinogenesis. / Crivellato, Enrico; Nico, Beatrice; Ribatti, Domenico.

In: Cancer Letters, Vol. 269, No. 1, 28.09.2008, p. 1-6.

Research output: Contribution to journalArticle

Crivellato, Enrico ; Nico, Beatrice ; Ribatti, Domenico. / Mast cells and tumour angiogenesis : New insight from experimental carcinogenesis. In: Cancer Letters. 2008 ; Vol. 269, No. 1. pp. 1-6.
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