Mast cells, angiogenesis and cancer

Domenico Ribatti, Enrico Crivellato

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Mast cells (MCs) were first described by Paul Ehrlich 1 in his doctoral thesis. MCs have long been implicated in the pathogenesis of allergic reactions and certain protective responses to parasites. As most tumors contain inflammatory cell infiltrates, which often include plentiful MCs, the question as to the possible contribution of MCs to tumor development has progressively been emerging. In this chapter, the specific involvement of MCs in tumor biology and tumor fate will be considered, with particular emphasis on the capacity of these cells to stimulate tumor growth by promoting angiogenesis and lymphangiogenesis. Data from experimental carcinogenesis and from different tumor settings in human pathology will be summarized. Information to be presented will suggest that MCs may serve as a novel therapeutic target for cancer treatment.

Original languageEnglish
Title of host publicationAdvances in Experimental Medicine and Biology
Pages270-288
Number of pages19
Volume716
DOIs
Publication statusPublished - 2011

Publication series

NameAdvances in Experimental Medicine and Biology
Volume716
ISSN (Print)00652598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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