Mast cells as a potential prognostic marker in prostate cancer

Gianluigi Taverna, Guido Giusti, Mauro Seveso, Rodolfo Hurle, Piergiuseppe Colombo, Sanja Stifter, Fabio Grizzi

Research output: Contribution to journalArticle


Despite years of intensive investigation that has been made in understanding prostate cancer, it remains one of the major mens health issues and the leading cause of deathworldwide. It is nowascertained that prostate cancer emerges frommultiple spontaneous and/or inherited alterations that induce changes in expression patterns of genes and proteins that function in complex networks controlling critical cellular events. It is nowaccepted that several innate and adaptiveimmune cells, including T- and B-lymphocytes, macrophages, natural killer cells, dendritic cells, neutrophils, eosinophils, and mast cells (MCs), infiltrate the prostate cancer. All of these cells are irregularly scattered within the tumor and loaded with an assorted array of cytokines, chemokines, and inflammatory and cytotoxic mediators. This complex framework reflects the diversity in tumor biology and tumor-host interactions.MCs arewellestablished effector cells in Immunoglobulin-E (Ig-E) associated immune responses and potent effector cells of the innate immune system; however, their clinical significance in prostate cancer is still debated. Here, these controversies are summarized, focusing on the implications of these findings in understanding the roles of MCs in primary prostate cancer.

Original languageEnglish
Pages (from-to)711-720
Number of pages10
JournalDisease Markers
Issue number6
Publication statusPublished - 2013

ASJC Scopus subject areas

  • Biochemistry, medical
  • Clinical Biochemistry
  • Molecular Biology
  • Genetics

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