Mast cells as therapeutic target in cancer

Domenico Ribatti

Research output: Contribution to journalArticlepeer-review

Abstract

Mast cells promote tumorigenesis and tumor progression, and have functions that favor the host. Increased mast cell number correlates with a poor prognosis in several human tumors. In different vascular tumors, as well as a number of hematological and solid tumors, mast cell accumulation correlate with increased neovascularization, tumor aggressiveness, and metastatic spread. Mast cells might act as a new target for the adjuvant treatment of tumors through the selective inhibition of angiogenesis, tissue remodeling and tumor-promoting molecules, permitting the secretion of cytotoxic cytokines and preventing mast cell-mediated immune suppression.

Original languageEnglish
JournalEuropean Journal of Pharmacology
DOIs
Publication statusAccepted/In press - Sep 4 2014

Keywords

  • Anticancer agents
  • Mast cells
  • Tryptase
  • Tumor growth
  • Tyrosine kinase inhibitors

ASJC Scopus subject areas

  • Pharmacology

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