Abstract
Mast cells promote tumorigenesis and tumor progression, and have functions that favor the host. Increased mast cell number correlates with a poor prognosis in several human tumors. In different vascular tumors, as well as a number of hematological and solid tumors, mast cell accumulation correlate with increased neovascularization, tumor aggressiveness, and metastatic spread. Mast cells might act as a new target for the adjuvant treatment of tumors through the selective inhibition of angiogenesis, tissue remodeling and tumor-promoting molecules, permitting the secretion of cytotoxic cytokines and preventing mast cell-mediated immune suppression.
| Original language | English |
|---|---|
| Journal | European Journal of Pharmacology |
| DOIs | |
| Publication status | Accepted/In press - Sep 4 2014 |
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Keywords
- Anticancer agents
- Mast cells
- Tryptase
- Tumor growth
- Tyrosine kinase inhibitors
ASJC Scopus subject areas
- Pharmacology
Cite this
Mast cells as therapeutic target in cancer. / Ribatti, Domenico.
In: European Journal of Pharmacology, 04.09.2014.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mast cells as therapeutic target in cancer
AU - Ribatti, Domenico
PY - 2014/9/4
Y1 - 2014/9/4
N2 - Mast cells promote tumorigenesis and tumor progression, and have functions that favor the host. Increased mast cell number correlates with a poor prognosis in several human tumors. In different vascular tumors, as well as a number of hematological and solid tumors, mast cell accumulation correlate with increased neovascularization, tumor aggressiveness, and metastatic spread. Mast cells might act as a new target for the adjuvant treatment of tumors through the selective inhibition of angiogenesis, tissue remodeling and tumor-promoting molecules, permitting the secretion of cytotoxic cytokines and preventing mast cell-mediated immune suppression.
AB - Mast cells promote tumorigenesis and tumor progression, and have functions that favor the host. Increased mast cell number correlates with a poor prognosis in several human tumors. In different vascular tumors, as well as a number of hematological and solid tumors, mast cell accumulation correlate with increased neovascularization, tumor aggressiveness, and metastatic spread. Mast cells might act as a new target for the adjuvant treatment of tumors through the selective inhibition of angiogenesis, tissue remodeling and tumor-promoting molecules, permitting the secretion of cytotoxic cytokines and preventing mast cell-mediated immune suppression.
KW - Anticancer agents
KW - Mast cells
KW - Tryptase
KW - Tumor growth
KW - Tyrosine kinase inhibitors
UR - http://www.scopus.com/inward/record.url?scp=84928957873&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928957873&partnerID=8YFLogxK
U2 - 10.1016/j.ejphar.2015.02.056
DO - 10.1016/j.ejphar.2015.02.056
M3 - Article
AN - SCOPUS:84928957873
JO - European Journal of Pharmacology
JF - European Journal of Pharmacology
SN - 0014-2999
ER -