Mast cells, basophils and eosinophils: From allergy to cancer

A Rigoni, M P Colombo, C Pucillo

Research output: Contribution to journalReview articlepeer-review


Basophils, eosinophils and mast cells were first recognized by Paul Ehrlich in the late 19th century. These cells have common, but non-redundant roles, in the pathogenesis of allergic diseases and in the protection against parasites. Nevertheless, in virtue of their shared-adeptness to produce a huge variety of immunological mediators and express membrane-bound receptors, they are able to interact with immune and non-immune components of the tissue microenvironment, contributing to the regulation of tissue homeostasis and immune response while participating to further deregulation of tissues transforming into neoplasia.

Original languageEnglish
Pages (from-to)29-34
Number of pages6
JournalSeminars in Immunology
Publication statusPublished - Feb 2018


  • Animals
  • Basophils/immunology
  • Cell Transformation, Neoplastic
  • Cellular Microenvironment
  • Eosinophils/immunology
  • Homeostasis
  • Humans
  • Hypersensitivity/immunology
  • Mast Cells/immunology
  • Neoplasms/immunology


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