Abstract
Basophils, eosinophils and mast cells were first recognized by Paul Ehrlich in the late 19th century. These cells have common, but non-redundant roles, in the pathogenesis of allergic diseases and in the protection against parasites. Nevertheless, in virtue of their shared-adeptness to produce a huge variety of immunological mediators and express membrane-bound receptors, they are able to interact with immune and non-immune components of the tissue microenvironment, contributing to the regulation of tissue homeostasis and immune response while participating to further deregulation of tissues transforming into neoplasia.
| Original language | English |
|---|---|
| Pages (from-to) | 29-34 |
| Number of pages | 6 |
| Journal | Seminars in Immunology |
| Volume | 35 |
| DOIs | |
| Publication status | Published - Feb 2018 |
Fingerprint
Keywords
- Animals
- Basophils/immunology
- Cell Transformation, Neoplastic
- Cellular Microenvironment
- Eosinophils/immunology
- Homeostasis
- Humans
- Hypersensitivity/immunology
- Mast Cells/immunology
- Neoplasms/immunology
Cite this
Mast cells, basophils and eosinophils : From allergy to cancer. / Rigoni, A; Colombo, M P; Pucillo, C.
In: Seminars in Immunology, Vol. 35, 02.2018, p. 29-34.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Mast cells, basophils and eosinophils
T2 - From allergy to cancer
AU - Rigoni, A
AU - Colombo, M P
AU - Pucillo, C
N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.
PY - 2018/2
Y1 - 2018/2
N2 - Basophils, eosinophils and mast cells were first recognized by Paul Ehrlich in the late 19th century. These cells have common, but non-redundant roles, in the pathogenesis of allergic diseases and in the protection against parasites. Nevertheless, in virtue of their shared-adeptness to produce a huge variety of immunological mediators and express membrane-bound receptors, they are able to interact with immune and non-immune components of the tissue microenvironment, contributing to the regulation of tissue homeostasis and immune response while participating to further deregulation of tissues transforming into neoplasia.
AB - Basophils, eosinophils and mast cells were first recognized by Paul Ehrlich in the late 19th century. These cells have common, but non-redundant roles, in the pathogenesis of allergic diseases and in the protection against parasites. Nevertheless, in virtue of their shared-adeptness to produce a huge variety of immunological mediators and express membrane-bound receptors, they are able to interact with immune and non-immune components of the tissue microenvironment, contributing to the regulation of tissue homeostasis and immune response while participating to further deregulation of tissues transforming into neoplasia.
KW - Animals
KW - Basophils/immunology
KW - Cell Transformation, Neoplastic
KW - Cellular Microenvironment
KW - Eosinophils/immunology
KW - Homeostasis
KW - Humans
KW - Hypersensitivity/immunology
KW - Mast Cells/immunology
KW - Neoplasms/immunology
U2 - 10.1016/j.smim.2018.02.001
DO - 10.1016/j.smim.2018.02.001
M3 - Review article
C2 - 29428698
VL - 35
SP - 29
EP - 34
JO - Seminars in Immunology
JF - Seminars in Immunology
SN - 1044-5323
ER -