Abstract
Basophils, eosinophils and mast cells were first recognized by Paul Ehrlich in the late 19th century. These cells have common, but non-redundant roles, in the pathogenesis of allergic diseases and in the protection against parasites. Nevertheless, in virtue of their shared-adeptness to produce a huge variety of immunological mediators and express membrane-bound receptors, they are able to interact with immune and non-immune components of the tissue microenvironment, contributing to the regulation of tissue homeostasis and immune response while participating to further deregulation of tissues transforming into neoplasia.
Original language | English |
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Pages (from-to) | 29-34 |
Number of pages | 6 |
Journal | Seminars in Immunology |
Volume | 35 |
DOIs | |
Publication status | Published - Feb 2018 |
Keywords
- Animals
- Basophils/immunology
- Cell Transformation, Neoplastic
- Cellular Microenvironment
- Eosinophils/immunology
- Homeostasis
- Humans
- Hypersensitivity/immunology
- Mast Cells/immunology
- Neoplasms/immunology